You may think you're just an average Joe, but according to your metabolomics data your body is percolating some expressive information about your daily life.
"Metabolomics measures small molecules called metabolites that reflect the physiology of the body, and can reveal specific details about you. Researchers can see specific metabolites -- such as caffeine -- in your blood, and form hypotheses about your diet, lifestyle or environment," said Stanford University School of Medicine Postdoctoral Fellow Tejaswini Mishra, Ph.D.
"For example, if we detected caffeine in your blood, it is likely that you had coffee before giving blood. With more data, we could also track your coffee-drinking habits, and perhaps even learn something about what type of coffee you drink! We might also see pesticides or derivatives of medications in the data, from which one could hypothesize whether a person gardens or farms, or lives in proximity to one, and which medications they might be on."
Mishra is integrating multi-omics data for NASA's Twins Study and comparing all the metabolites in retired twin astronauts Scott and Mark Kelly. She saw a number of Scott's metabolites increase in levels when he went to space and when he returned to Earth some of those stayed elevated. By integrating data from other Twins Study investigations, she hopes they can determine the cause of this elevation.
"It is incredible and powerful to have such rich data but it also is a little scary," Mishra said. "It really underscores the importance of securing your personal data, who you share it with, how you store it and protect it."
Twins Study researchers are investigating and securing an unprecedented amount of information. Most studies focus on two or three types of data but this is one of the few studies integrating many different types of data. By comparing identical genomes from twins, researchers can focus more attention to other specific molecular changes, such as metabolomics changes involving the end products of various biological pathways and processes.
Mishra is helping to integrate data from metabolites, DNA, RNA, proteins, microbes, physiological and neurobehavioral systems, as well as food and exercise logs, to help researchers create a timeline and identify patterns and correlations. Together, they hope to help identify health-associated molecular effects of spaceflight to protect astronauts on future missions.
NASA's Human Research Program (HRP) is dedicated to discovering the best methods and technologies to support safe, productive human space travel. HRP enables space exploration by reducing the risks to astronaut health and performance using ground research facilities, the International Space Station and analog environments. This leads to the development and delivery of a program focused on: human health, performance and habitability standards; countermeasures and risk-mitigation solutions; and advanced habitability and medical-support technologies. HRP supports innovative, scientific human research by funding more than 300 research grants to respected universities, hospitals and NASA centers to over 200 researchers in more than 30 states.
NASA Human Research Strategic Communications
Amy Blanchett | EurekAlert!
Broadband achromatic metalens focuses light regardless of polarization
21.01.2019 | Harvard John A. Paulson School of Engineering and Applied Sciences
Lifting the veil on the black hole at the heart of our Galaxy
21.01.2019 | Max-Planck-Institut für Radioastronomie
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
21.01.2019 | Life Sciences
21.01.2019 | Physics and Astronomy
21.01.2019 | Life Sciences