Women who smoke and carry specific variations in the genes that impact their metabolism are at higher risk of developing hot flashes in comparison with smokers who do not carry these gene variants, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM).
Previous studies have shown that smoking is associated with earlier onset of menopause, increased odds of hot flashes and risk of postmenopausal osteoporosis. The current study aimed to explore which smokers have the highest risk of hot flashes based on the presence of variants in specific genes involved in hormone metabolism as well as activation of toxins in tobacco smoke.
"Our report demonstrates the impact of smoking on hot flashes as a function of variants in genes involved in sex steroid metabolism in late reproductive-age women and suggests that certain smokers have increased susceptibility to hot flashes based on their genetic background," said Samantha Butts, MD MSCE, of the Perelman School of Medicine at the University of Pennsylvania and the study's lead author. "Women who smoke and carry a particular gene variant may benefit from aggressive targeted approaches to smoking cessation, especially if they know that smoking is a significant contributor to their menopausal symptoms."
In this study, researchers examined 296 late reproductive-aged women who have been followed for the past eleven years in the Penn Ovarian Aging Study, a population based study of reproductive aging. Butts and colleagues took blood samples from study participants and evaluated their medical and reproductive history, menopausal symptoms and behaviors such as smoking and alcohol consumption. They found that women who smoked and carried single nucleotide polymorphisms (SNPs) in certain genes were at a significantly higher risk for developing hot flashes than smokers who did not carry these SNPs.
"The toxins in cigarette smoke that are believed to be associated with hot flashes are also present in many forms in the environment which means even non-smokers who have certain SNPs could be at risk for symptoms," said Butts. "Furthermore, it's possible that smoking behaviors in women carrying relevant SNPs could impact health risks well into menopause and could challenge reproductive success in young women aiming to become pregnant, making this an even broader public health consideration."
Other researchers working on the study include: Ellen W. Freeman, Mary D. Sammel, Kaila Queen, Hui Lin and Timothy Rebbeck of the University of Pennsylvania.
The article, "Joint Effects of Smoking and Gene Variants Involved in Sex Steroid Metabolism on Hot Flashes in Late Reproductive-Age Women," appears in the June 2012 issue of JCEM.
Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 15,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at www.endo-society.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.
Aaron Lohr | EurekAlert!
Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern
Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz
DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.
The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...
Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.
The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...
Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.
Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...
The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.
A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...
Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
11.03.2019 | Event News
01.03.2019 | Event News
28.02.2019 | Event News
22.03.2019 | Life Sciences
22.03.2019 | Life Sciences
22.03.2019 | Information Technology