Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Some women may be genetically predisposed to smoking-related hot flashes

03.05.2012
New study shows smokers with variants in specific genes at greater risk for hot flashes

Women who smoke and carry specific variations in the genes that impact their metabolism are at higher risk of developing hot flashes in comparison with smokers who do not carry these gene variants, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM).

Previous studies have shown that smoking is associated with earlier onset of menopause, increased odds of hot flashes and risk of postmenopausal osteoporosis. The current study aimed to explore which smokers have the highest risk of hot flashes based on the presence of variants in specific genes involved in hormone metabolism as well as activation of toxins in tobacco smoke.

"Our report demonstrates the impact of smoking on hot flashes as a function of variants in genes involved in sex steroid metabolism in late reproductive-age women and suggests that certain smokers have increased susceptibility to hot flashes based on their genetic background," said Samantha Butts, MD MSCE, of the Perelman School of Medicine at the University of Pennsylvania and the study's lead author. "Women who smoke and carry a particular gene variant may benefit from aggressive targeted approaches to smoking cessation, especially if they know that smoking is a significant contributor to their menopausal symptoms."

In this study, researchers examined 296 late reproductive-aged women who have been followed for the past eleven years in the Penn Ovarian Aging Study, a population based study of reproductive aging. Butts and colleagues took blood samples from study participants and evaluated their medical and reproductive history, menopausal symptoms and behaviors such as smoking and alcohol consumption. They found that women who smoked and carried single nucleotide polymorphisms (SNPs) in certain genes were at a significantly higher risk for developing hot flashes than smokers who did not carry these SNPs.

"The toxins in cigarette smoke that are believed to be associated with hot flashes are also present in many forms in the environment which means even non-smokers who have certain SNPs could be at risk for symptoms," said Butts. "Furthermore, it's possible that smoking behaviors in women carrying relevant SNPs could impact health risks well into menopause and could challenge reproductive success in young women aiming to become pregnant, making this an even broader public health consideration."

Other researchers working on the study include: Ellen W. Freeman, Mary D. Sammel, Kaila Queen, Hui Lin and Timothy Rebbeck of the University of Pennsylvania.

The article, "Joint Effects of Smoking and Gene Variants Involved in Sex Steroid Metabolism on Hot Flashes in Late Reproductive-Age Women," appears in the June 2012 issue of JCEM.

Founded in 1916, The Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, The Endocrine Society's membership consists of over 15,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at www.endo-society.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.

Aaron Lohr | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>