Computed tomographic colonography (CTC), also known as virtual colonoscopy, administered without laxatives is as accurate as conventional colonoscopy in detecting clinically significant, potentially cancerous polyps, according to a study performed jointly at the San Francisco VA Medical Center, the University of California, San Francisco and Massachusetts General Hospital.
"I think we have demonstrated that laxative-free CTC is a valid tool for detecting polyps that are clinically significant," said co-author and site principal investigator Judy Yee, MD, chief of radiology at SFVAMC and professor and vice chair of radiology at UCSF.
The study was published in the May 15 issue of Annals of Internal Medicine.
Virtual colonoscopy, which has been approved by the American Cancer Society as a valid screening test for colorectal cancer, uses a CT scanner to screen for cancers and polyps in the colon non-invasively. In standard optical colonoscopy (OC), a physician inserts a six-foot-long scope into the entire colon. Currently, both methods call for patients to take a bowel-cleansing laxative before the procedure.
With laxative-free CTC, explained Yee, patients do not have to go through bowel cleansing before the exam, but instead begin a low fiber diet two days before the test. They also ingest a tagging agent the day before the exam, which mixes with residual material in the colon and can then be identified and removed digitally when radiologists interpret the scans.
"The use of laxatives is often viewed as the worse aspect of having not only a virtual colonoscopy but an optical colonoscopy," said Yee, who has pioneered the use of virtual colonoscopy within the VA health care system and at UCSF. "I hope that this research will encourage patients who have delayed screening for colon cancer to be examined with this less invasive method."
The study of 605 patients, aged 50 to 85, assessed the accuracy of laxative-free CTC in detecting lesions 6 millimeters or larger in size compared with standard optical colonoscopy.
The authors found that laxative-free CTC exams detected clinically significant polyps 10 mm or larger with 91 percent accuracy compared to OC exams, which were 95 percent accurate. Statistically, there is no difference between these two numbers, said Yee.
Scan sensitivity using laxative-free CT colonography decreases with polyp size, as it does for regular CT colonography, she said. With polyps measuring 6 mm, sensitivity for CTC was 59 percent, compared with standard colonoscopy at 76 percent.
The smaller the polyp, the less likely it is to harbor malignancy. For diminutive polyps 5 mm or less, there is an extremely low risk of cancer, and these polyps may not need to be removed.
For polyps between 6 and 9 mm in size, the decision about whether to remove them depends on the patient's risk factors and how many are found, said Yee.
"Polyps 10 millimeters or larger unquestionably come out," she said.
During the study, three of the 605 subjects were found to have cancerous polyps. The cancers were identified by both the laxative-free virtual colonoscopy and the standard OC exam.
The researchers also surveyed the research participants about their experiences while preparing for the examinations. They found that laxative-free virtual colonoscopy scored higher on all survey questions, and was indicated by more participants to be their exam type of choice.
Yee noted that the current study is one of the first and largest to measure the effectiveness of the new, laxative-free procedure. Because the procedure is still in the early stages of development, additional studies still need to be conducted, she said.
She predicts that once radiologists are trained in reading the new images and gain experience with the exam process, laxative-free CTC exams will be available wherever virtual colonoscopies are performed.
Co-authors of the study are Michael E. Zalis, MD, Michael A. Blake, MB, BCh, Wenli Cai, PhD, Peter F. Hahn, MD, PhD, Elkan F. Halpern, PhD, Imarana G. Kazam, PhD, Myles Keroack, MD, Cordula Magee, PhD, Janne J. Nappi, PhD, Rocio Perez-Johnston, MD, Abhinav Vij, MD and Hiroyuki Yoshida, PhD, of Massachusetts General Hospital, and John R. Saltzman, MD, of Brigham and Women's Hospital, Boston, Massachusetts.
The authors had no conflicts of interest.
The study was supported by funds from GE Healthcare and the American Cancer Society, some of which were administered by the Northern California Institute for Research and Education.
NCIRE – The Veterans Health Research Institute – is the largest research based institute associated with a VA medical center. Its mission is to improve the health and well-being of veterans and the general public by supporting a world-class biomedical research program conducted by the UCSF faculty at SFVAMC.
SFVAMC has the largest medical research program in the national VA system, with more than 200 research scientists, all of whom are faculty members at UCSF.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
Steve Tokar | EurekAlert!
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy