Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

VascuBone – a toolbox for customised vascularised bone implants

09.06.2015

The EU project VascuBone was coordinated by the Fraunhofer Institute for In-terfacial Engineering and Biotechnology IGB and has reached the end of a 5-year funding period. In March 2015, the partners of this international research consortium met at the Würzburg Congress Centre to discuss the results of this successful project. The focus of the meeting was the newly developed “Vascu-Bone Toolbox” to apply advanced materials and tailor-made combinations to individualized bone defects.

The final meeting of the EU project VascuBone took place on March 30-31, 2015 in the Würzburg Congress Centre. The goal of this project was to improve bone implants depending on the defect, to minimize the risk of rejection while supporting the body’s own regenerative potential, and to promote new bone growth in different bone defects.


Cells on calcium phoshate: cell skeleton (red), cell connections (green), cell nuclei (blue).

The international consortium and invited guests met to evaluate the results of the original and innovative project goals. Nineteen partners from four European countries were involved during the whole funding period.

The greatest innovation in the past five years is the “VascuBoneToolbox,” which provides various components required for a customised bone implant that supports the body’s own self-healing capacity when it cannot meet its own regenerative needs following severe damage or injury.

The toolbox is comprised of three major components. The first component is a novel, diamond-coated ceramic granulate material with large pores. This material can be readily used as it is easily absorbed in defects, is biocompatible and facilitates the growth of bone cells.

The second major component is proteins acquired from the patient’s own blood to help promote bone tissue growth. The third component consists of cells from the patient’s blood or bone marrow that ensure that the implant is not rejected. Until now, surgeons have used either metal-based implants or tissue transplanted from a patient’s own pelvic bone.

“There are drawbacks to both options: metal remains a foreign material on the surface of which new bone cannot form. Tissue from a patient’s pelvis would be ideal but there is a limit to how much can be removed,” explained VascuBone project coordinator Heike Walles.

The biologist is professor of Tissue Engineering and Regenerative Medicine at the Würzburg University Hospital and Director of the Translational Centre “Regenerative Therapies for Oncology and Musculoskeletal Diseases” of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB’s Würzburg branch.

The VascuBone researchers were already able to demonstrate in pre-clinical trials that the bone implants from the VascuBone “Toolbox” did not accelerate the growth of tumours. Various tests also showed that the implants were also ideal for regenerating bone that is weakened with age. Clinical trials are now underway that will allow the use of the implants in patients within a few years.

The project partners used the meeting to bring together the scientific findings regarding the implant construction and individual functionalisation with autologous cells and proteins. Quality control measures and imaging that have been implemented and the associated studies and tests were then presented. The relevance of tissue engineering was highlighted both from an industrial perspective and in terms of scientific research.

This research has received funding from the European Union’s Seventh Framework Programme under grant agreement no. 242175.

Weitere Informationen:

http://www.igb.fraunhofer.de/en/press-media/press-releases/2015/vascubone-_-a-to...

Dr. Claudia Vorbeck | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

More articles from Health and Medicine:

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

nachricht Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Subaru Telescope helps pinpoint origin of ultra-high energy neutrino

16.07.2018 | Physics and Astronomy

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides

16.07.2018 | Life Sciences

New research calculates capacity of North American forests to sequester carbon

16.07.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>