Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UT-research: better outcome prediction of postanoxic coma

23.06.2015

EEG-measurements enable better prediction of the outcome of a coma that was caused by a lack of oxygen to the brain. This became clear from research of the University of Twente (MIRA) in cooperation with Rijnstate hospital and MST.

A new method helps to make reliable and correct estimates in about 50% of patients, instead of only 10% of patients with the methods currently used. This involves continuous EEG-measurements focussing on the speed with which the brain's activity recovers. It seems that recovery over time is a better indicator of the severity of brain damage than single brief measurements, which are currently done.

Half of the patients with a post-anoxic coma (a coma resulting from lack of oxygen to the brain) never regain consciousness. It is exceptionally difficult to reliably predict which patients are and which are not capable of recovering. Currently, prediction is based on clinical measurements of the depth of the coma in combination with a so-called SSEP measurement. This provides a correct estimate for only ten percent of patients. This is why doctor, and also family-members, need an instrument that is better at determining which patients do and which do not have a chance of recovery.

First 24 hours

Performing a continuous EEG measurement and looking at improvement of brain activity allows a correct estimate in half of the patients. This is shown by research of the University of Twente in cooperation with Rijnstate hospital and Medisch Spectrum Twente.

The published research, which involves data from approximately 300 patients, was carried out during the period from 2011 to 2014. This is the largest dataset ever used for research of EEG in postanoxic coma. According to the first author, dr. Jeannette Hofmeijer (assistant professor at the University of Twente and neurologist at Rijnstate hospital), who set up this research together with prof. dr. ir. Michel van Putten (chairholder Clinical Neurophysiology at the UT and neurologist/clinical neurophysiologist at the MST), EEG based outcome prediction showed less reliable results in previous studies. In the current study, prediction improved importantly by looking at the EEG differently.

Instead of using a single EEG measurement, EEG measurements were now made continuously. A single measurement provides insufficient reliable information about the severity of the brain damage and the chance of recovery. Otherwise, by looking at changes in brain activity over time, much more information can be obtained from the EEG.

Improvement of brain activity measured in the first 24 hours is crucial: if there is sufficient improvement within twelve hours, a good recovery can be predicted with a high level of probability, while the prognosis is invariably poor if there is insufficient improvement within 24 hours. Being able to determine the chance of recovery at an early stage provides doctors and families with better information about whether continuation of intensive care treatment makes sense.

Research
The research was initiated and set up by dr. Jeannette Hofmeijer and prof. dr. ir. Michel van Putten and carried out in cooperation with Tim Beernink (medical doctor at Rijnstate), dr. Frank Bosch (intensivist Rijnstate), dr. Albertus Beishuizen (intensivist MST) and dr. Marleen Tjepkema-Cloostermans (technical medicine UT and MST). The research was partly funded by the Dutch Ministry of Economic Affairs, Agriculture and Innovation, province Overijssel and Gelderland (ViP Brain Networks project). Marleen Tjepkema-Cloostermans obtained het PhD in the subject at the University of Twente in 2014.

Medical-ethical questions
This improvement in diagnostics is a step forward, but means doctors and family-members are faced with new important medical-ethical questions. Such as: when are the prospects of a coma-patient so poor that stopping treatment is justified? In a new study, doctors and philosophers at the UT's MIRA research institute will start searching for answers to these and other ethical questions. That study will start in the middle of this year and is being funded by the Netherlands Organization for Scientific Research (NWO), the Netherlands Brain Foundation, Clinical Science Systems and Twente Medical Systems International.

Note for the press
For more information, interview requests, or a digital version of the article Early EEG contributes to multimodal outcome prediction of postanoxic coma, please contact the UT Science Information Officer, Joost Bruysters (06 1048 8228).

drs Joost Bruysters | idw - Informationsdienst Wissenschaft
Further information:
http://www.utwente.nl/en/research/

Further reports about: EEG activity brain damage early stage ethical questions measurement

More articles from Health and Medicine:

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

nachricht Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Microscopic trampoline may help create networks of quantum computers

17.07.2018 | Information Technology

In borophene, boundaries are no barrier

17.07.2018 | Materials Sciences

The role of Sodium for the Enhancement of Solar Cells

17.07.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>