Lupus is a chronic inflammatory disease that can affect the skin, joints, kidneys, lungs, nervous system and other organs of the body. The underlying causes of lupus are unknown, but it is usually more common in women of child-bearing age.
For this new study, a collaborative team of UC and Cincinnati Children's researchers wanted to compare lupus rates between people who were exposed to uranium and those who were not in an effort to explain the high number of lupus cases reported in a Cincinnati community.
Extensive review of medical records and serum antibody analysis to verify the cases, concluded that people who were exposed to higher levels of uranium, based on their living proximity to a former uranium ore processing plant, had lupus rates four times higher than the average population.
"Former studies have suggested that people with lupus may be more sensitive to radiation and that both genetics and environmental exposures play a role in disease development. Our study shows a strong correlation between uranium exposure, a radioactive substance, and an increased lupus rate that merits further investigation," says Pai-Yue Lu, MD, a pediatric rheumatology fellow at Cincinnati Children's and lead researcher for the study.
"With more research in this area, we may gain additional insight on the types of environmental factors that contribute to lupus development and the mechanisms by which they work," Lu adds. "There could be other effects of uranium and related exposures that could contribute to or help explain our findings."
Lu is presenting this finding and its potential implication at the American College of Rheumatology Annual Scientific Meeting Monday, Nov. 12, in Washington, D.C. She completed the project as part of her master's degree in clinical and translational science training at UC.
The Cincinnati-based team's research is based on nearly two decades of data collected through the Fernald Medical Monitoring Program, the United States' first and largest legally mandated comprehensive medical monitoring program. The program was established in 1990 after a federal investigation revealed that National Lead of Ohio's Feed Materials Production Center in the Hamilton County, Ohio, community of Fernald, was emitting dangerous levels of uranium dust and gases into the surrounding communities.
"The availability of this cohort and carefully collected data and biospecimens provides a great setting to ask research questions," says Susan Pinney, PhD, UC professor of environmental health and principal investigator of the Fernald study.
Almost 10,000 community residents enrolled in the Fernald Medical Monitoring Program. Community residents were classified into several exposure groups: high exposure, moderate exposure, low exposure and no exposure. (Uranium plant workers were not part of this study.)
"Typical U.S. incidence rates for lupus are 1.8 to 7.6 cases per 100,000. Among the 25 confirmed lupus cases we identified through the Fernald community cohort, 12 were in the high exposure group, eight with moderate exposure and five in the low exposure group," says Lu.
Research was supported by a pilot grant from a Center for Environmental Genetics, a National Institute of Environmental Health Sciences-funded program to support core facilities and technologies needed to conduct innovative research that focuses on how environmental agents interact with genetic and epigenetic factors to influence disease risk and outcome. Shuk-mei Ho, PhD, Jacob A. Schmidlapp Chair and Professor of Environmental Health, serves as principal investigator of the CEG grant.
Amanda Harper | EurekAlert!
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology