Technique can be used to better categorize patients with neurological disease, according to their therapeutic needs
Personalized medicine - delivering therapies specially tailored to a patient's unique physiology - has been a goal of researchers and doctors for a long time. New research provides a way of delivering personalized treatments to patients with neurological disease.
Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University and the Ludmer Centre for Neuroinformatics and Mental Health have developed what they call a personalized Therapeutic Intervention Fingerprint (pTIF).
The pTIF predicts the effectiveness of targeting specific biological factors (brain amyloid/tau deposition, inflammation, neuronal functional dysregulation) for controlling the evolution of the patient's disease. Their results were published in the journal Neuroimage on June 14, 2018.
Lead by the study's first author, Yasser Iturria-Medina, researchers used computational brain modeling and artificial intelligence techniques to analyze the neurological data from 331 Alzheimer's patients and healthy controls. The data included multiple modes of positron emission tomography (PET) and magnetic resonance imaging (MRI). From this, Iturria-Medina and colleagues were able to categorize patients into their TIF subtypes, according to the potentially most beneficial factor-specific interventions.
The authors verified these subtypes were relevant by comparing them to the patients' individual genetic profiles. They found patients in the same pTIF subtype had similar gene expression, meaning the mechanism in which genes affect their physiology is similar. Because drugs to control disease progression would have to modify gene expression and brain properties at the same time, drugs tailored to pTIF subtypes would be much more effective than drugs designed to treat all Alzheimer's disease patients.
This is the first study to pinpoint a direct link between brain dynamics, predicted therapeutic responses, and molecular and cognitive alterations in patients. Using pTIF subtypes, drugs can be designed for a patient's unique gene expression profile and phenotypic brain characteristics, which is a major advancement in personalized medicine. It could also improve the effectiveness and reduce the cost of clinical drug trials if used as a method to select patients.
"In keeping with the tenets of personalized medicine, the introduced framework could lead to more effective medical care, decreased undesired secondary effects, and substantial reduction of pharmaceutical/clinical costs associated with clinical trials, thereby accelerating the creation-evaluation cycle of new therapeutic agents,´ says Iturria-Medina. "Our future work will focus on applying the pTIF to other neurological disorders, extensively validating it, and, importantly, making the resulting analytic tools available to the international community, via open-access platforms."
This research was funded by the Government of Canada's Banting postdoctoral fellowship and Brain Canada through the Canada Brain Research Fund with the financial support of Health Canada, whereas data collection was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) and its associated institutions.
The Montreal Neurological Institute and Hospital - The Neuro - is a world-leading destination for brain research and advanced patient care. Since its founding in 1934 by renowned neurosurgeon Dr. Wilder Penfield, The Neuro has grown to be the largest specialized neuroscience research and clinical center in Canada, and one of the largest in the world. The seamless integration of research, patient care, and training of the world's top minds make The Neuro uniquely positioned to have a significant impact on the understanding and treatment of nervous system disorders. The Montreal Neurological Institute is a McGill University research and teaching institute. The Montreal Neurological Hospital is part of the Neuroscience Mission of the McGill University Health Centre.
For more information, please visit http://www.
Shawn Hayward | EurekAlert!
Neutrons produce first direct 3D maps of water during cell membrane fusion
21.09.2018 | DOE/Oak Ridge National Laboratory
Narcolepsy, scientists unmask the culprit of an enigmatic disease
20.09.2018 | Universitätsspital Bern
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
21.09.2018 | Event News
03.09.2018 | Event News
27.08.2018 | Event News
21.09.2018 | Physics and Astronomy
21.09.2018 | Life Sciences
21.09.2018 | Event News