Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Umeå researchers even closer to early detection of Parkinson’s disease

26.09.2012
In collaboration with colleagues at Oxford, a team of researchers at Umeå University in Sweden has now further elaborated its discovery of a way to detect Parkinson’s disease at an early stage, and applications in clinical care are not far away.
The project is an example of bridging the gap between basic and clinical research in care environments. The new findings are based on close cooperation between the medical chemist Ludmilla Morozova-Roche’s and the neurologist Lars Forsgren’s research teams at Umeå University and Jason Davis's team at Oxford University in the UK, who were primarily responsible for the chemical analyses. Their findings are now being published in the journal Chemical Science.

Parkinson’s disease attacks the nervous system and, like many other diseases, is caused by proteins that lump together into so-called amyloid. Behind these new findings lies a discovery from the spring of 2011, when the Umeå scientists were able to determine endogenous antibodies against the most important amyloid protein, alpha-synuclein. These antibodies were seen as being able to function as a diagnostic marker, thereby enabling early detection of the disease.

In the new article the discovery is elaborated further in the form of a simplified way to carefully measure the content of antibodies in a blood sample. With the newly developed method – this involves electrochemical analysis of 10 microliters of blood in just a few minutes – it is possible not only to see a clear difference between individuals with incipient Parkinson’s disease and healthy controls but also to measure and establish the advance of the disease with great precision.

Press photo of Ludmilla Morozova-Roche
For more information, please contact:

Ludmilla Morozova-Roche, professor of medical biophysics at the Department of Medical Chemistry and Biophysics, Umeå University, phone: +46 (0)90-786 52 83, Mobile: +46 (0)73-620 52 83
E-mail ludmilla.morozova-roche@medchem.umu.se
Reference

T Bryan, X Luo, L Forsgren, L Morozova-Roche and JJ Davis. The robust electrochemical detection of a Parkinson’s disease marker in whole blood sera

Chemical Science, DOI: 10.1039/c2sc21221h

Karin Wikman | idw
Further information:
http://www.rsc.org/chemicalscience
http://pubs.rsc.org/en/content/articlepdf/2012/sc/c2sc21221h?page=search

More articles from Health and Medicine:

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

nachricht Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

Im Focus: A molecular switch may serve as new target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz- Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. The results of the study have just been published in the prestigious scientific journal 'Molecular Cell'.

Cell growth and cell differentiation as well as the release and efficacy of hormones such as insulin depend on the presence of lipids. Lipids are small...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Can radar replace stethoscopes?

14.08.2018 | Medical Engineering

The end-Cretaceous extinction unleashed modern shark diversity

14.08.2018 | Life Sciences

Light-controlled molecules: Scientists develop new recycling strategy

14.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>