Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UIC researchers find unique organ-specific signature profiles for blood vessel cells

18.02.2020

Probing the molecular biology of blood vessels in the heart, brain and lungs

Researchers from the University of Illinois at Chicago have discovered that endothelial cells -- those that create the inner lining of blood vessels -- have unique genetic signatures based on their location in the body.


Fluorescence microscopy image of the lung with blood vessel endothelial cells shown in green and non-endothelial cells in red.

Credit: Jalees Rehman

Their study, which is published in the journal eLife, used a genetic mouse model to compare endothelial cells in their natural organ environment. The researchers first looked at healthy mice and compared how genes were expressed in endothelial cells from heart, lung and brain tissues. Next, they studied the blood vessel endothelial cells of unhealthy mice -- those exposed to a bacterial toxin, which mimicked inflammation in the whole body.

Under both conditions, endothelial cells from various organs expressed distinct genetic signatures.

"One of the most surprising findings of this study is that blood vessel endothelial cells in the brain express genes that were previously thought to be primarily found in neurons -- such as the genes involved in the transport of neurotransmitters and synaptic vesicles," said Dr. Jalees Rehman, UIC professor of medicine, pharmacology and bioengineering at the College of Medicine.

Similar results were found for heart endothelial cells, which expressed the genes known to help heart muscle cells beat and pump blood.

"We have had anecdotal descriptions that blood vessel cells function differently in each organ for some time, but newer genetic tools allowed us to perform a global analysis of thousands of genes in the blood vessels of these vital organs," Rehman said.

Rehman said the results of this study can be used to inform the bioengineering of blood vessels that are specific to different organs and that the findings suggest there are untapped avenues for developing more targeted treatments.

"Our findings provide organ-specific blood vessel 'ZIP codes' for the potential delivery of drugs to specific tissues," Rehman said. "Right now, most treatments for vascular disease target all blood vessels regardless of where they are. Imagine if we could develop more effective treatments to uniquely improve the function of blood vessels in the heart or the brain?"

Rehman said that this research suggests that blood vessels may play previously unrecognized roles in some neurological diseases such as Alzheimer's disease and other forms of dementia because the brain's endothelial cells expressed genes involved in cognitive function.

###

Co-authors on the paper include UIC's Ankit Jambusaria, Zhigang Hong, Lianghui Zhang, Shubhi Srivastava, Arundhati Jana, Peter Toth, Yang Dai, and Asrar Malik.

This research was conducted with support from the National Institutes of Health (R01HL126515, R01HL90152, P01HL60678 and T32HL007829).

Media Contact

Jackie Carey
jmcarey@uic.edu
312-996-8277

 @uicnews

http://www.uic.edu 

Jackie Carey | EurekAlert!
Further information:
https://today.uic.edu/uic-researchers-find-unique-organ-specific-signature-profiles-for-blood-vessel-cells
http://dx.doi.org/10.7554/eLife.51413

More articles from Health and Medicine:

nachricht New 3D cultured cells mimic the progress of NASH
02.04.2020 | Tokyo University of Agriculture and Technology

nachricht Geneticists are bringing personal medicine closer to recently admixed individuals
02.04.2020 | Estonian Research Council

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: When ions rattle their cage

Electrolytes play a key role in many areas: They are crucial for the storage of energy in our body as well as in batteries. In order to release energy, ions - charged atoms - must move in a liquid such as water. Until now the precise mechanism by which they move through the atoms and molecules of the electrolyte has, however, remained largely unknown. Scientists at the Max Planck Institute for Polymer Research have now shown that the electrical resistance of an electrolyte, which is determined by the motion of ions, can be traced back to microscopic vibrations of these dissolved ions.

In chemistry, common table salt is also known as sodium chloride. If this salt is dissolved in water, sodium and chloride atoms dissolve as positively or...

Im Focus: Harnessing the rain for hydrovoltaics

Drops of water falling on or sliding over surfaces may leave behind traces of electrical charge, causing the drops to charge themselves. Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz have now begun a detailed investigation into this phenomenon that accompanies us in every-day life. They developed a method to quantify the charge generation and additionally created a theoretical model to aid understanding. According to the scientists, the observed effect could be a source of generated power and an important building block for understanding frictional electricity.

Water drops sliding over non-conducting surfaces can be found everywhere in our lives: From the dripping of a coffee machine, to a rinse in the shower, to an...

Im Focus: A sensational discovery: Traces of rainforests in West Antarctica

90 million-year-old forest soil provides unexpected evidence for exceptionally warm climate near the South Pole in the Cretaceous

An international team of researchers led by geoscientists from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) have now...

Im Focus: Blocking the Iron Transport Could Stop Tuberculosis

The bacteria that cause tuberculosis need iron to survive. Researchers at the University of Zurich have now solved the first detailed structure of the transport protein responsible for the iron supply. When the iron transport into the bacteria is inhibited, the pathogen can no longer grow. This opens novel ways to develop targeted tuberculosis drugs.

One of the most devastating pathogens that lives inside human cells is Mycobacterium tuberculosis, the bacillus that causes tuberculosis. According to the...

Im Focus: Physicist from Hannover Develops New Photon Source for Tap-proof Communication

An international team with the participation of Prof. Dr. Michael Kues from the Cluster of Excellence PhoenixD at Leibniz University Hannover has developed a new method for generating quantum-entangled photons in a spectral range of light that was previously inaccessible. The discovery can make the encryption of satellite-based communications much more secure in the future.

A 15-member research team from the UK, Germany and Japan has developed a new method for generating and detecting quantum-entangled photons at a wavelength of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

13th AKL – International Laser Technology Congress: May 4–6, 2022 in Aachen – Laser Technology Live already this year!

02.04.2020 | Event News

“4th Hybrid Materials and Structures 2020” takes place over the internet

26.03.2020 | Event News

 
Latest News

TU Dresden chemists develop noble metal aerogels for electrochemical hydrogen production and other applications

06.04.2020 | Life Sciences

Lade-PV Project Begins: Vehicle-integrated PV for Electrical Commercial Vehicles

06.04.2020 | Power and Electrical Engineering

Lack of Knowledge and Uncertainty about Algorithms in Online Services

06.04.2020 | Social Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>