Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Trudeau Institute announces its latest discovery in the fight against tuberculosis

19.10.2011
Research shows connection between development of new lymphoid tissue within the lung and protection against tuberculosis

New research from the Trudeau Institute may help in the ongoing fight against tuberculosis. Dr. Andrea Cooper's lab has discovered a connection between the development of new lymphoid tissue within the lung and protection against the disease. The new data will be published in the November 1 print issue of The Journal of Immunology (Vol. 187, Num. 10) and is available now online ahead of print.

Tuberculosis (TB for short) is a deadly infectious disease caused by infection with Mycobacterium tuberculosis that affects many people throughout the world. Tuberculosis normally attacks the lungs, but can also affect other parts of the body. It is spread through the air when people with active TB infection cough, sneeze or otherwise transmit their saliva through the air. Left untreated, TB can kill more than 50 percent of its victims.

"In the model examined by my laboratory, the absence of a specific cytokine resulted in poor development of new lymphoid tissue," said Dr. Cooper. "There was an associated loss of a molecule that helps recruit protective cells from the blood to the site of infection within the lung. Although this lymphoid tissue has been seen in tuberculosis lesions in the lung in the past, this is the first time that this part of the immune response has been associated with an active role in protection against tuberculosis."

By understanding how different components of the immune response control the bacteria that cause tuberculosis, public health officials/health practitioners will be better positioned to protect against the disease with a combination of vaccination, immunotherapeutics and drugs. The new findings could prove particularly useful as cells within this lymphoid tissue have not been previously targeted by vaccination and may provide novel avenues to improve current vaccines.

The research was performed by current and past members of the Trudeau Institute, including scientists from the University of Pittsburgh and the University of Rochester. Dr. Shabaana Khader, Dr. Javier Rangel-Moreno and Dr. Troy Randall were also involved with the study.

Dr. Cooper's studies are funded by the Trudeau Institute and grants from the National Institutes of Health.

About the Trudeau Institute

The Trudeau Institute is an independent, not-for-profit, biomedical research organization, whose scientific mission is to make breakthrough discoveries leading to improved human health. Trudeau researchers are identifying the basic mechanisms used by the immune system to combat viruses like influenza, mycobacteria, such as tuberculosis, parasites and cancer, so that better vaccines and therapies can be developed for fighting deadly disease.

The research is supported by government grants and philanthropic contributions.

Kim Godreau | EurekAlert!
Further information:
http://www.trudeauinstitute.org

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

Im Focus: Revealing the secret of the vacuum for the first time

New research group at the University of Jena combines theory and experiment to demonstrate for the first time certain physical processes in a quantum vacuum

For most people, a vacuum is an empty space. Quantum physics, on the other hand, assumes that even in this lowest-energy state, particles and antiparticles...

Im Focus: Sussex scientists one step closer to a clock that could replace GPS and Galileo

Physicists in the EPic Lab at University of Sussex make crucial development in global race to develop a portable atomic clock

Scientists in the Emergent Photonics Lab (EPic Lab) at the University of Sussex have made a breakthrough to a crucial element of an atomic clock - devices...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Molecular motors run in unison in a metal-organic framework

20.03.2019 | Life Sciences

Active substance from plant slows down aggressive eye cancer

20.03.2019 | Life Sciences

Novel sensor system improves reliability of high-temperature humidity measurements

20.03.2019 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>