Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transplantation : Researchers from ULB developed a mouse model of vascularized bone tranplantation

17.12.2008
More and more composite tissue grafts are worldwide performed. This kind of graft implies to take a sample of all necessary tissues and vascular and nervous elements for the reconstruction of a given area.

This includes elbow, arm, hand and face transplantations and requires surgical skill and a multidisciplinary approach. Because in these cases transplanted tissues are always coming from a genetically non-identical donor (allograft), they generate a rejection process mediated by the recipient immune system.

Therefore, chronic immunosuppression is required to prevent rejection and graft loss, with some side effects that may limit the indication of transplantation based on logic of cost-benefit ratio. The ideal solution would be to get reliable protocols for inducing transplantation tolerance.

Very recently, funded by the Melina Nakos foundation and the First Elite program of the Walloon region, and in collaboration with Professor Frédéric Schuind from Erasme hospital, doctors Zanzhuo Li and Alain Le Moine, at the Institute for Medical Immunology – Université libre de Bruxelles (ULB), developed a mouse model of composite tissue allograft including a vascularised femur.

The results of their research are published in the American Journal of Transplantation, the official journal of the American Society of Transplantation (AST).

In this model, a short course of immunosuppression at the time of transplantation allowed to make recipients robustly tolerant to the transplant. Importantly, tolerance was donor-specific, since recipients were still able to reject a third party allograft (unrelated to the donor), meaning that recipient immune system ultimately recovered responsiveness. It was shown that donor-type haematopoietic stem cells derived from the transplanted bone repopulated the recipient immune system and induced tolerance by removing anti-donor cells. This did not require recipient aggressive preconditioning which is considered as a too risky treatment to be applied in the context of composite tissue allografts. Therefore, vascularized bone transplantation containing donor-derived bone marrow cells might become a valuable tool for inducing transplantation tolerance in composite tissue allografts but also in other transplantations.

This study demonstrates the feasibility of stem cells grafts through a vascularised bone and the tolerance that it induces in the recipient of a composite tissue allograft.

In terms of clinical applications, this could be an alternative method to the intravenous injection of stem cells which does not induce a stable chimerism in the recipient unless after a heavy conditioning of the patient.

Zhanzhuo L, Benghiat FS, Kubjak C, Noval Rivas M, Cobbold S, Waldmann H, Petein M, Schuind F, Goldman M, Le Moine A. CD8+ T cell depletion and rapamycin synergize with signal 1 and 2 blockade to induce robust limb allograft tolerance in mice. Am J Transplant 2008 ; 8 : 1-10.

For scientific informations :
Alain Le Moine, IMI-ULB, +32 (0) 2 650 95 51, alemoine@ulb.ac.be

Nancy Dath | alfa
Further information:
http://ulb.ac.be

More articles from Health and Medicine:

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

nachricht Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Microscopic trampoline may help create networks of quantum computers

17.07.2018 | Information Technology

In borophene, boundaries are no barrier

17.07.2018 | Materials Sciences

The role of Sodium for the Enhancement of Solar Cells

17.07.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>