This includes elbow, arm, hand and face transplantations and requires surgical skill and a multidisciplinary approach. Because in these cases transplanted tissues are always coming from a genetically non-identical donor (allograft), they generate a rejection process mediated by the recipient immune system.
Therefore, chronic immunosuppression is required to prevent rejection and graft loss, with some side effects that may limit the indication of transplantation based on logic of cost-benefit ratio. The ideal solution would be to get reliable protocols for inducing transplantation tolerance.
Very recently, funded by the Melina Nakos foundation and the First Elite program of the Walloon region, and in collaboration with Professor Frédéric Schuind from Erasme hospital, doctors Zanzhuo Li and Alain Le Moine, at the Institute for Medical Immunology – Université libre de Bruxelles (ULB), developed a mouse model of composite tissue allograft including a vascularised femur.
The results of their research are published in the American Journal of Transplantation, the official journal of the American Society of Transplantation (AST).
In this model, a short course of immunosuppression at the time of transplantation allowed to make recipients robustly tolerant to the transplant. Importantly, tolerance was donor-specific, since recipients were still able to reject a third party allograft (unrelated to the donor), meaning that recipient immune system ultimately recovered responsiveness. It was shown that donor-type haematopoietic stem cells derived from the transplanted bone repopulated the recipient immune system and induced tolerance by removing anti-donor cells. This did not require recipient aggressive preconditioning which is considered as a too risky treatment to be applied in the context of composite tissue allografts. Therefore, vascularized bone transplantation containing donor-derived bone marrow cells might become a valuable tool for inducing transplantation tolerance in composite tissue allografts but also in other transplantations.
This study demonstrates the feasibility of stem cells grafts through a vascularised bone and the tolerance that it induces in the recipient of a composite tissue allograft.
In terms of clinical applications, this could be an alternative method to the intravenous injection of stem cells which does not induce a stable chimerism in the recipient unless after a heavy conditioning of the patient.
Zhanzhuo L, Benghiat FS, Kubjak C, Noval Rivas M, Cobbold S, Waldmann H, Petein M, Schuind F, Goldman M, Le Moine A. CD8+ T cell depletion and rapamycin synergize with signal 1 and 2 blockade to induce robust limb allograft tolerance in mice. Am J Transplant 2008 ; 8 : 1-10.For scientific informations :
Nancy Dath | alfa
New flexible, transparent, wearable biopatch, improves cellular observation, drug delivery
12.11.2018 | Purdue University
Exosomes 'swarm' to protect against bacteria inhaled through the nose
12.11.2018 | Massachusetts Eye and Ear Infirmary
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.
Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
12.11.2018 | Life Sciences
12.11.2018 | Materials Sciences
12.11.2018 | Physics and Astronomy