Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Therapy Optimisation by Analysing the Genome

13.05.2019

The University Hospital Bonn plans to have a stronger focus on pharmacogenetics – thus emphasising the influence of genetic characteristics on the effect of medications. This idea embodies the approach for personalised medicine. To integrate extensive pharmacogenetic analysis into the clinical workflow, the Institute of Human Genetics at the University Hospital Bonn and HMG Systems Engineering GmbH (HMG) are establishing a partnership. The intended purpose is to provide the treating physician with clinically relevant information regarding pharmacologic and genetic interaction risks. That way, physicians are empowered to optimize the individual drug therapy for each patient.

Each human metabolises medication differently. Similar to the diverse factors forming diseases, the influences on the effect and tolerance of the prescribed medicine tend to be multifaceted. In addition to the age, weight, lifestyle and nutrition habits, and the intake of further medicines, patients’ genetic characteristics also impact the desired therapeutic effect.


In the lab: Prof. Dr. Markus Nöthen, Director of the Institute of Human Genetics at the University Hospital Bonn.

© Photo: Volker Lannert / Uni Bonn

In consideration of selected characteristics in the genome, pharmacogenetics enables an individual optimisation of the medication. Thus, patient-related risks and side effects can be reduced.

"The development of personalised therapies is making great progress."

"The pharmacogenetic profile of a patient can be critical in determining an optimal medication. Especially when several drugs are prescribed and interactions between them are to be expected," says Prof. Dr. Markus Nöthen, director of the Institute for Human Genetics at the University Hospital Bonn.

With its scientific working groups, it contributes to the research of the genetic causes of diseases and to the development of effective, individually tailored drug therapies and preventive measures.

“The partnership will enable us to use the innovative software and database developed by HMG and to introduce high-level pharmacogenetic diagnostics. In addition, a pilot project for patients at the University Hospital Bonn will be developed in the coming months. It is our vision that patients at our clinic benefit from the latest scientific knowledge in genetic medicine," says Prof. Nöthen.

“The future of medical technology is personalised medicine”

HMG has developed an IT platform, which interprets clinically relevant genetic information of the patient and its influences on individual drug metabolism. The software consists of own pharmacogenetic database. Considering 173 genetic variations, it constitutes the current state of research and is based upon up-to-date findings of science.

The database is complemented by a drug interactions check, evaluating the interactions of 40,000 drugs and 60 food and beverages. This enables physicians to optimise the patient’s medication in an even more precise, safe and efficient way.

“We are convinced that this medical technology will prospectively provide the appropriate drug with the right dose at the right time for each patient. We are delighted to partner with the renowned Institute of Human Genetics at the University Hospital Bonn and Prof. Markus Nöthen. Together we are taking a major step to translate pharmacogenetics basic research to clinical routine and medical prescription,” says Herna Muñoz-Galeano, founder and managing director of HMG Systems Engineering GmbH.

For more information about the Institute of Human Genetics at the University Hospital Bonn:
https://www.humangenetics.uni-bonn.de/

For more information about HMG Systems Engineering GmbH:
https://www.hmg-systems-engineering.com

Media contacts:

Prof. Dr. Markus Nöthen
Director of the Institute of Human Genetics
University Hospital Bonn
Telefon: 0228/ 287-51100
E-mail: markus.noethen@uni-bonn.de

Herna Muñoz-Galeano
Managing director HMG Systems Engineering GmbH
Bettina Hofmann
Marketing & Communikations
HMG Systems Engineering GmbH
Telefon: 0911/ 97 91 08 57
E-mail: bettina.hofmann@munoz-galeano.com

Johannes Seiler | idw - Informationsdienst Wissenschaft
Further information:
http://www.uni-bonn.de/

More articles from Health and Medicine:

nachricht Study points to new drug target in fight against cancer
19.09.2019 | Rice University

nachricht Researchers develop tumour growth roadmap
19.09.2019 | Universität Leipzig

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 'Nanochains' could increase battery capacity, cut charging time

How long the battery of your phone or computer lasts depends on how many lithium ions can be stored in the battery's negative electrode material. If the battery runs out of these ions, it can't generate an electrical current to run a device and ultimately fails.

Materials with a higher lithium ion storage capacity are either too heavy or the wrong shape to replace graphite, the electrode material currently used in...

Im Focus: Stevens team closes in on 'holy grail' of room temperature quantum computing chips

Photons interact on chip-based system with unprecedented efficiency

To process information, photons must interact. However, these tiny packets of light want nothing to do with each other, each passing by without altering the...

Im Focus: Happy hour for time-resolved crystallography

Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.

The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.

Im Focus: Modular OLED light strips

At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.

Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...

Im Focus: Tomorrow´s coolants of choice

Scientists assess the potential of magnetic-cooling materials

Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Technologies: International Symposium „Future Optics“ in Hannover

19.09.2019 | Event News

Society 5.0: putting humans at the heart of digitalisation

10.09.2019 | Event News

Interspeech 2019 conference: Alexa and Siri in Graz

04.09.2019 | Event News

 
Latest News

Quality control in immune communication: Chaperones detect immature signaling molecules in the immune system

20.09.2019 | Life Sciences

Moderately Common Plants Show Highest Relative Losses

20.09.2019 | Life Sciences

The Fluid Fingerprint of Hurricanes

20.09.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>