Can stillbirth be prevented? Investigating this question, researchers at Inselspital and the Society for the Investigation of Early Pregnancy have discovered a potential prevention mechanism for preterm deliveries.
Inflammatory response during pregnancy is the leading cause of preterm loss. Depending on its degree, it may also lead to preterm birth. A team of researchers from Bern and Rome in cooperation with BioIncept Inc. found that a synthetic version of the PreImplantation Factor (PIF), endogenously present in viable embryos, reduces the inflammatory response during pregnancy. The study results were published in the June 12 issue of PLOS One.
“PIF modulates key elements of the inflammatory pathway namely the inflammasome complex,” explains corresponding author PD Dr. Martin Mueller, Senior Attending in the Department of Gynaecology and Obstetrics at Inselspital, Bern University Hospital, and Visiting Assistant Professor in the Department of Obstetrics, Gynaecology and Reproductive Sciences at Yale School of Medicine. “This mechanism is the first to allow influencing inflammatory response during pregnancy.”
Using a model, Mueller and the team found that PIF reduces foetal loss, reverses the inflammatory response and improves fetal growth. A series of clinically relevant in vivo and in vitro experiments demonstrated that PIF modulates the inflammasome complex in the placenta.
Lead author Nicoletta Di Simone, Professor in the Department of Obstetrics and Gynaecology at Università Cattolica Del Sacro Cuore in Rome, was astonished at the results: “In summary, our findings suggest that PIF protects the pregnancy against an inflammatory insult.”
“This novel pathway is promising and encourages us to pursue this new line of investigation,” said co-author Dr. Daniel Surbek, Professor and Head of the Department of Gynaecology and Obstetrics and feto-maternal medicine at Inselspital. “Given the common inflammatory origin of fetal loss and preterm birth, we may even have a new powerful treatment to prevent both,” he says.
PIF was first discovered and characterized by Eytan Barnea, founder of the Society for the Investigation of Early Pregnancy (SIEP) and chief scientific officer at BioIncept, LLC. Based on his data, the FDA has awarded PIF fast-track designation, resulting in a recently completed first clinical trial to treat patients with autoimmune liver disease at the University of Miami.
In Bern, the research team is now evaluating the possibility of a clinical trial with pregnant subjects. The goal would be to use PIF prophylactically to prevent preterm birth in high-risk pregnancies.
PD Dr. Dr. med. Martin Müller, Senior Attending in the Department of Gynaecology and Obstetrics at Inselspital, Bern University Hospital, contact via firstname.lastname@example.org, +41 31 632 79 25.
Monika Kugemann | idw - Informationsdienst Wissenschaft
Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz
Scientists find new approach that shows promise for treating cystic fibrosis
14.03.2019 | NIH/National Heart, Lung and Blood Institute
The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.
A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...
Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
New research group at the University of Jena combines theory and experiment to demonstrate for the first time certain physical processes in a quantum vacuum
For most people, a vacuum is an empty space. Quantum physics, on the other hand, assumes that even in this lowest-energy state, particles and antiparticles...
Physicists in the EPic Lab at University of Sussex make crucial development in global race to develop a portable atomic clock
Scientists in the Emergent Photonics Lab (EPic Lab) at the University of Sussex have made a breakthrough to a crucial element of an atomic clock - devices...
Every year earthquakes worldwide claim hundreds or even thousands of lives. Forewarning allows people to head for safety and a matter of seconds could spell...
11.03.2019 | Event News
01.03.2019 | Event News
28.02.2019 | Event News
19.03.2019 | Physics and Astronomy
19.03.2019 | Life Sciences
19.03.2019 | Physics and Astronomy