Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New targets for treatment of diarrhoeal diseases discovered by RCSI researchers

29.11.2010
A study by researchers in the Royal College of Surgeons in Ireland (RCSI) has uncovered a potential new target for the treatment of a range of intestinal diseases that are associated with diarrhoea. Current medications are often ineffective and can have serious side effects so this discovery gives hope for the development of new treatments for sufferers of intestinal disease.

Worldwide, almost 2 million children die each year as a result of infectious diarrhoea1, however, diarrhoeal diseases are also very common in developed countries. “Diarrhoea associated intestinal disorders, such as irritable bowel syndrome (IBS), Crohn’s disease, colitis, coeliac disease and microbial infections are a major health issue in Ireland.

It is estimated that between 40,000 and 50,000 people visit their local Gastroenterology clinic each year2 seeking treatment for diarrhoea. The cost to the Irish economy in terms of healthcare costs and lost working days is immense,” commented Dr Stephen Keely, senior author on the study and Associate Director of the RCSI Molecular Medicine Lab at Beaumont Hospital.

Explaining the findings of the research study, Dr Keely said: ‘Current treatments for intestinal diseases are not targeted specifically enough and as a result can be ineffective or have serious side effects. Working with researchers in UCD and TCD, we have discovered that a type of protein, known as hydroxylases, play a key role in regulating water and salt transport in the intestines. Our experimental results suggest that by inhibiting the activity of these proteins, diarrhoea can be prevented. The discovery gives us a promising new target for the development of drugs to treat intestinal diseases that have diarrhoea as a primary symptom. Because such drugs would act directly on the cells responsible for controlling water movement in the intestine, they would potentially have better outcomes and reduced side effects for patients,” Dr Keely concluded.

The lead author on the paper is Joseph Ward who conducted the research as part of his PhD studies along with Dr Karen Lawler and Dr Keely from the Molecular Medicine Laboratories in RCSI. The team also collaborated with Prof Padraic Fallon from the Institute of Molecular Medicine, Trinity College Dublin, and Prof Cormac Taylor of the Conway Institute at University College Dublin.

This work was published in the Federation of American Societies for Experimental Biology (FASEB) Journal in October 2010 and was funded by Science Foundation Ireland and the Higher Education Authority’s Programme for Research in Third Level Institutions (PRTLI) Cycle 4, as part of the National Biophotonics Imaging Platform (NBIP) Ireland.

Full bibliographic information
Ward J.B.J., Lawler K., Amu S., Taylor C.T., Fallon P.G., Keely S.J (2010). Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. FASEB Journal, October 2010

fj.10-166983 http://www.fasebj.org/content/early/2010/10/27/fj.10-166983.abstract

Jane Butler | alfa
Further information:
http://www.rcsi.ie

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>