Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a regulator that initiates and hastens wound healing by triggering the inflammatory reaction. Their discovery is now being published in the highly ranked journal Blood.
“Today we have the knowledge needed to develop a medicine,” says Professor Tor Ny, one of the authors of the article. “The bulk of the preclinical research has been completed, and we have been in contact with the Medical Products Agency to discuss a program for clinical testing.”
Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Umeå researchers have re-evaluated its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic sores the level of plasminogen does not rise in the same way, and this seems to be the reason why these sores do not heal. In mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected into the sore, which then heals fully.
A cell line for producing plasminogen on a larger scale has also been developed, and the goal is to be able to start clinical testing as soon as funding can be arranged. The researchers have high hopes, as plasminogen is an endogenous substance that can be assumed not to produce side effects.
The need for a biological pharmaceutical for treating intractable wounds is pressing indeed. Diabetic sores that heal poorly or not at all are the most severe type of chronic sores, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Today’s treatment of diabetic ulcers consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.The Umeå researchers are initially concentrating on diabetic wounds, but the medicine has great potential for working on other types of stubborn sores. This includes damaged eardrums and periodontitis. The new pharmaceutical has moreover been shown to be helpful in combatting antibiotic-resistant bacteria (MRSA).
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences