Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sodium MRI gives new insights into detecting osteoarthritis

30.08.2010
Researchers at New York University have developed an innovative way to look at the development of osteoarthritis in the knee joint—one that relies on the examination of sodium ions in cartilage. Their work, which appears in the Journal of Magnetic Resonance, may provide a non-invasive method to diagnose osteoarthritis in its very early stages.

The concentration of sodium ions, which are distributed in the body, is known to reveal the location of glycosaminogycans (GAGs) in cartilage tissues. GAGs are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Mapping the GAG concentration is necessary for the diagnosis and monitoring of a number of diseases as well as to determine the efficacy of drug therapies. For instance, GAG loss in cartilage typically marks the onset of osteoarthritis and inter-vertebral disc degeneration.

However, the existing techniques for GAG monitoring—based on traditional magnetic resonance imaging (MRI)—have limitations: they cannot directly map GAG concentrations or they require the administration of contrast agents to reveal the location of these concentrations.

But since sodium ions are already present in cartilage, researchers have sought to measure these ions using special MRI techniques that are non-invasive.

Such a methodology was previously developed at the University of Pennsylvania and Stanford University. However, these methodologies were not able to isolate ions in different parts of the knee area. Specifically, they could not make clear-cut distinctions between signals of slow motion sodium ions in the cartilage from those of free sodium ions in synovial fluid and joint effusion in the knee joint.

The NYU research team sought to improve on this method by focusing on the differences in the properties of sodium ions in the two environments.

Since sodium is present not only in cartilage, MRI images often cannot tell whether the sodium concentration measured is located in cartilage or elsewhere in the knee joint. To better target where these sodium concentrations reside, the researchers focused on the differences in the magnetic behavior of sodium ions residing in different tissues. By exploiting these characteristic properties of sodium ions in different environments, the research team was able to develop a new method to isolate two pools of sodium ions. As a result, it was able to obtain images in which the sodium signals appear exclusively from regions with cartilage tissue.

This new sodium MRI method not only could provide a non-invasive way to diagnose osteoarthritis in its very early stages, but could also help to calibrate other, less direct measures of cartilage assessments.

The research was conducted by: Alexej Jerschow, an associate professor, and Jae-Seung Lee, a post-doctoral fellow, both in NYU's Department of Chemistry; Ravinder Regatte, an associate professor, and Guillaume Madelin, a post-doctoral fellow, both in the Radiology Department at NYU School of Medicine; and Souheil Inati, a former assistant professor at NYU's Center for Neural Science and currently a staff scientist at the National Institute of Mental Health.

James Devitt | EurekAlert!
Further information:
http://www.nyu.edu

Further reports about: Gag MRI MRI technique magnetic resonance imaging sodium

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>