New research published online in The FASEB Journal (http://www.fasebj.org) details research in rats and mice that offers hope for stopping the devastating, and often fatal, effects of sepsis in humans. In the study, University of Michigan researchers show how neutralizing the effects of a key protein fragment, called C5a, used by the immune system to attract white blood cells may ultimately prevent heart failure.
"During sepsis, heart failure is a common feature of the later stages of the syndrome," said Peter A. Ward, M.D., a senior scientist involved in the work from the Department of Pathology at the University of Michigan Health Systems in Ann Arbor, MI. "The current studies in experimental sepsis suggest that cardiomyocytes interact with the powerful complement-derived C5a anaphylatoxin, resulting in release of cardiosuppressive cytokines that may be linked with defective cardiomyocyte function developing during sepsis."
To make their discovery, Ward and colleagues obtained specialized heart muscle cells, called "cardiomyocytes" (CMs), from normal rats and incubated them in the laboratory with C5a. They found that the cardiomyocyes released specialized immune cells, called cytokines (IL-6 and TNF alpha), in a time-dependent and dose-dependent manner. Sepsis was also induced in mice, and CMs isolated from these mice and examined in vitro. The scientists found that these cells spontaneously released a variety of cytokines, several of which appeared to have the potential to harm the heart. When other mice with beginning stages of sepsis were injected with an antibody to neutralize C5a, the activity of the heart-harming cytokines was reduced. Furthermore, when mice bred to lack receptors for C5a were subjected to sepsis, little or no spontaneous release of cytokines from heart cells occurred.
"Under the best circumstances, sepsis is unpredictable and difficult to treat," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journa1, "It's perhaps the most serious problem in emergency medicine and when sepsis affects the heart it moves from serious to grave. Now that we know that C5a is at least partly responsible, antibodies to C5a promise to get to the heart of the problem."
According to the National Institute of General Medical Sciences, NIH, Sepsis is a major challenge in the intensive care unit, where it is one of the leading causes of death. It is caused when immune chemicals released into the blood to combat infection trigger widespread inflammation, resulting in impaired blood flow, which damages the body's organs by depriving them of nutrients and oxygen. In the worst cases, the heart weakens and multiple organs—lungs, kidneys, liver—may quickly fail and the patient can die. Each year, severe sepsis strikes about 750,000 Americans, and as many as half die, which is more than the number of U.S. deaths from prostate cancer, breast cancer and AIDS combined.
Receive monthly highlights from The FASEB Journal by signing up at http://www.faseb.org/fjupdate.aspx or you can "like" the Federation of American Societies for Experimental Biology on Facebook. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB) and celebrates its 25th anniversary in 2011. Over the past quarter century, the journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information.
FASEB comprises 23 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improve—through their research—the health, well-being and productivity of all people. FASEB's mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
Details: Gelareh Atefi, Firas S. Zetoune, Todd J. Herron, José Jalife, Markus Bosmann, Rami Al-Aref, J. Vidya Sarma, and Peter A. Ward. Complement dependency of cardiomyocyte release of mediators during sepsis. FASEB J. doi:10.1096/fj.11-183236 ; http://www.fasebj.org/content/early/2011/04/08/fj.11-183236.abstract
Cody Mooneyhan | EurekAlert!
Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences