The study, to be published tomorrow for Cancer Clinical Research ( available online Oct 1,) has found that this analysis of Circulating Tumour Cells (CTC) can be utilised to study the prognosis of prostate cancer and is an independent indicator for overall survival of the disease.
Lead researcher Dr Johann de Bono at The Institute of Cancer Research and The Royal Marsden Hospital says:
“CTC testing, used in conjunction with the existing prostate specific antigen (PSA) test, may allow doctors to more accurately evaluate the effect of treatment on a patient’s tumour.”
“These studies are a very promising development, allowing cancer cells to be detected using a simple blood test and may eventually allow us to tailor cancer treatments to maximise the benefit for patients. Hopefully this will lead to improving the survival of patients with metastatic prostate cancer.”
The PSA test has been widely adopted as the benchmark test for prostate cancer in the UK, but it is not always possible to identify a clear relationship between a raised PSA level and the status of the disease.
Circulating tumour cells (CTCs) are cancer cells that have broken away from an existing tumour and have entered into the bloodstream. The presence of these cells in the blood provides valuable insights into disease progression.
This study has shown that the monitoring and detection of CTCs can provide valuable information on the patient’s prognosis. Further studies are taking place to evaluate if the CTC test may be used to allow doctors to make treatment decisions more quickly and more reliably for the benefit of patients.
The test has already been incorporated into several prostate cancer drug trials that are taking place at The Institute and The Royal Marsden.
The test has been cleared by the FDA in the United States to determine the prognosis of patients with metastatic breast, colorectal or prostate cancer.
The study was in partnership with the New-York based Memorial Sloan-Kettering Institute and involved 231 patients undergoing chemotherapy treatment. Sixty-five clinical centres in Europe and the U.S. took part in the study.
The patients underwent monthly CTC monitoring to measure the level of circulating tumour cells in the blood. A count of more than 5 CTC per 7.5 ml of blood was seen as an indicator towards an “unfavourable” prognosis whereas a count of less than 5 CTC per 7.5ml was considered “favourable”. This was compared with the progression of the metastatic prostate cancer tumours.
Cathy Beveridge | alfa
Researchers image atomic structure of important immune regulator
11.12.2018 | Brigham and Women's Hospital
Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
10.12.2018 | Event News
06.12.2018 | Event News
03.12.2018 | Event News
11.12.2018 | Physics and Astronomy
11.12.2018 | Materials Sciences
11.12.2018 | Information Technology