As antiviral treatment for HIV infection allows patients to live longer, many will be confronted with additional health challenges. A new study shows for the first time that one of these may be significantly increased risk of bone fractures.
The report in the September Journal of Clinical Endocrinology and Metabolism finds that fracture prevalence was increased more than 60 percent in those infected with HIV compared to patients without HIV infection.
"This is the largest investigation to date to compare fracture rates in HIV-infected patients with those of non-infected controls," says Steven Grinspoon, MD, of the Massachusetts General Hospital (MGH) Neuroendocrine Unit and Program in Nutritional Metabolism, the report's senior author. "This very large study group – with more than 8,500 HIV-infected patients and over two million controls – has the power to detect significant differences in risk for both men and women at critical sites such as the hip and spine, risks that increased with age."
Previous studies of the impact of HIV on bone health focused on bone density and reported increased prevalence of osteoporosis and the less-serious condition osteopenia in HIV-infected men and women, but evaluation of the consequences of these conditions was limited. For the current study, the investigators utilized the Partners HealthCare System Research Patient Data Registry, which includes demographic and diagnostic information on patients treated at MGH and Brigham and Women's Hospital.
Their analysis of data from patients treated over an 11-year period revealed that almost 2.9 percent of HIV patients were diagnosed with fractures of the hip, spine or wrist, while fracture prevalence was only 1.8 percent in non-HIV-infected patients. HIV-associated increases in fracture rates were seen in both men – 3 percent versus 1.8 percent – and women – 2.5 percent versus 1.7 percent; and the increased risk was even more pronounced in older patients.
"These data indicate that we should screen HIV-infected patients, both men and women, for low bone density as they age." Grinspoon says. "We also need to learn more about the mechanisms of this bone loss – whether antiviral drugs, the virus itself, or other metabolic factors are responsible – and investigate specific fracture rates for women before and after menopause." Grinspoon is a professor of Medicine at Harvard Medical School.
Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering
New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
18.12.2018 | Materials Sciences
18.12.2018 | Physics and Astronomy
18.12.2018 | Physics and Astronomy