Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers study joints at tissue, cellular levels

25.07.2012
Cleveland Clinic team simulates cartilage response to loading

A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads – virtual models that someday can be used to understand damage mechanisms caused by the aging process or debilitating diseases, such as osteoarthritis.


A macro-scale model of the knee (left) was created to study compressive loading of the joint. At the micro scale, the single-cell model (top, right) has been used in previous studies, while Erdemir’s 11-cell model better represents the effects of loading on the individual cells. (Erdemir/Cleveland Clinic)


Erdemir’s finite element model of the knee joint with representation of the cartilage, menisci and the associated bone structures. An enlarged model region (right) illustrates the mesh resolution of the simulation. (Erdemir/Cleveland Clinic)

Led by Ahmet Erdemir, Ph.D., the team is leveraging the powerful computing systems of the Ohio Supercomputer Center to develop state-of-the-art computational representations of the human body to understand how movement patterns and loads on the joints deform the surrounding tissues and cells. Erdemir is the director of the Computational Biomodeling Core (CoBi) and a faculty member in the Department of Biomedical Engineering at the Lerner Research Institute (LRI) in Cleveland, Ohio.

“The aging process and debilitating diseases affect many aspects of the mechanical function of the human body: from the way we move to how our muscles, joints, tissues, and cells accommodate the loading exerted on the body during daily activities,” Erdemir explained. “Computational modeling techniques provide an avenue to obtain additional insights about mechanics at various spatial scales.”
Many macro-scale studies have looked at how the various components of a knee joint – cartilage, menisci, ligaments and bone – respond to weight and other external loads. However, Erdemir and colleague Scott C. Sibole wanted to better understand how those large mechanical forces correspond to the related deformation of individual cartilage cells – or chondrocytes – within the knee. Previous micro-scale studies of cartilage have not commonly been based on data from body-level scales, in particular, by the musculoskeletal mechanics of the knee joint.

In addition, calculated deformations typically have been for a single cell at the center of a 100-cubic-micrometer block of simulated tissue; Erdemir used an anatomically based representation that calculated deformations for 11 cells distributed within the same volume.

“In both micro-scale approaches, the cartilage cells experienced amplified deformations compared to those at the macro-scale, predicted by simulating the compression of tissues in the knee joint under the weight of the body,” Erdemir found. “In the 11-cell case, all cells experienced less deformation than the single cell case, and also exhibited a larger variance in deformation compared to other cells residing in the same block.”

Erdemir’s method proved to be highly scalable because of micro-scale model independence that allowed exploitation of distributed memory computing architecture. As a result, Sibole, a research engineer at LRI, was able to leverage the computational muscle of OSC’s IBM 1350 Glenn Cluster. At the time, the 9,500 nodes of the Glenn Cluster provided 75 teraflops of computing power, tech-speak for 75 trillion calculations per second. Recently, the Glenn Cluster was partially decommissioned when engineers deployed the center’s more powerful HP-Intel Xeon Oakley Cluster.

“Both of OSC’s two most recent flagship computing systems were specifically designed to support biomedical applications, such as those employed by Dr. Erdemir and Mr. Sibole,” said Ashok Krishnamurthy, OSC interim co-executive director. “Researchers working at Ohio’s various respected medical centers are conducting an ever-increasing load of computational studies and analyses, and they now represent a significant share of our user community.”

An article authored by Erdemir and Sibole, “Chondrocyte Deformations as a Function of Tibiofemoral Joint Loading Predicted by a Generalized High-Throughput Pipeline of Multi-Scale Simulations,” was recently published in PLoS ONE, an international, peer-reviewed, open-access, online journal. Grant funding from the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health supported the study.

The Ohio Supercomputer Center (OSC), a member of the Ohio Technology Consortium of the Ohio Board of Regents, addresses the rising computational demands of academic and industrial research communities by providing a robust shared infrastructure and proven expertise in advanced modeling, simulation and analysis. OSC empowers scientists with the vital resources essential to make extraordinary discoveries and innovations, partners with businesses and industry to leverage computational science as a competitive force in the global knowledge economy, and leads efforts to equip the workforce with the key technology skills required to secure 21st century jobs. For more, visit www.osc.edu.

The Department of Biomedical Engineering (BME) at the Lerner Research Institute is committed to investigation, innovation, and translation of scientific discoveries to enhance patient care. The Lerner Research Institute is home to Cleveland Clinic's laboratory-based, translational and clinical research. For more, visit www.lerner.ccf.org/bme.

Jamie Abel | EurekAlert!
Further information:
http://www.oh-tech.org

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Laser processing is a matter for the head – LZH at the Hannover Messe 2019

25.03.2019 | Trade Fair News

A Varied Menu

25.03.2019 | Life Sciences

‘Time Machine’ heralds new era

25.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>