Dr Benjamin Tang, University of Western Sydney, Sydney, Australia, and colleagues based their findings on a meta-analysis (a pooled analysis of previous trials) of 17 studies featuring 52625 people all aged over 50 years, with an average treatment time of 3.5 years. They found that where the compliance rate was high (i.e. patients were sticking to the dosing regimen correctly), there was a 24% fracture risk reduction.
The risk reductions were better with calcium doses of over 1200mg compared with doses of less than 1200mg (20% versus 6% reduction), and with vitamin D doses of 800 IU (international units) or more than with does less than 800IU (16% reduction versus 13% reduction). The treatment effect was also greater in individuals who were elderly, lived in institutions, had a low bodyweight, had a low calcium intake, or were at a higher baseline risk than other individuals. The authors believe those in institutions may have benefited more due to assistance complying with the dosing regimen, eg. by nurses making sure patients took their supplements when required.
In a separate part to the study, the researchers did a meta-analysis of 23 trials that reported bone density as an outcome, and found that calcium supplementation alone, or in combination with vitamin D supplementation also reduced the rate of bone loss at the hip by 0.54% and at the spine by 1.19%.
The authors conclude: “Our meta-analysis has shown that calcium supplementation, alone or in combination with vitamin D, is effective in the preventive treatment of osteoporotic fracture… poor compliance is a major obstacle to obtaining the full benefit of calcium supplementation.”
They add: “Although addition of vitamin D supplementation was not shown to offer additional risk reduction over and above the use of calcium alone, a significant difference was observed between the effects of different vitamin D doses.”
In an accompanying Comment, Dr Jean-Yves Reginster, Bone and Cartilage Metabolism Unit, Liege, Belgium, says: “Unlike previous meta-analyses, Tang provides clear answers to several questions which could be of immediate practical importance for the daily management of osteoporosis….Tang and colleagues contribution is important because it paves the way for future research aiming at the best clinical, pharmacological, and economic optimisation of the use of calcium and vitamin D in patients at increased risk of osteoporotic fractures.”
Tony Kirby | alfa
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences