Burns trigger an immediate, dramatic inflammatory response, as well as a more delayed and longer-lasting hypermetabolic one. The latter can cause depletion of essential proteins, reduced bone density and muscle strength, and can compromise the function of vital organs. But whilst it’s well known that increased burn size leads to increased mortality in burned patients, the roles played by inflammation and hypermetabolism are less clear.
Marc G. Jeschke from Shriners Hospitals for Children, Texas, USA and colleagues conducted a prospective clinical trial of 189 paediatric burned patients over nine years to see if burn size is associated with differences in inflammation, body composition, protein synthesis and organ function.
Burn injuries involving more than 80% of the total body surface cause marked and prolonged inflammation, increases in hypermetabolism, catabolism, cardiac dysfunction and subsequently higher incidences of infection, sepsis and death. These effects were burn size-dependent. Another outstanding finding was that effect of burn size on cardiac dysfunction. Only large burns caused cardiac dysfunction which was shown by Pereira et al. as one of the major contributor to mortality, implying the importance of adequate cardiovascular support and treatment.
Patients with larger burns also had higher levels of pro-inflammatory cytokines, such as Tumor Necrosis Factor and Interleukin-8. The authors think these give the inflammatory response an added boost, enhancing catabolism and hypermetabolism.
Charlotte Webber | alfa
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences