Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique for detecting cardiac fibrosis

21.03.2002


A medical team of the Basque Country has discovered a new technique to detect cardiac fibrosis. After a research carried out during several years, it has been discovered that serum leves of PIP peptide is an indicator of increased myocardial fibrosis.



Fibrosis is formed when scar tissue is accumulated in heart. As a consequence it causes stiffening of the heart and often heart failure. In order to fight against such disease, researchers started looking for an indicator substance in blood.

Collagen amount and PIP


This research started 10 years ago with spontaneoulsy hypertensive rats. As a result, they could find out that hypertensive disease increases the amount of heart collagen. On the other hand, researchers did know that in some other diseases, like cirrhosis of the liver, collagen amount used to increase. It was also well known that in such disease the serum amount of PIP substance (carboxyterminal peptide of type 1 procollagen) was high. Hence, could it be possible that this peptide shows also which patientes are accumulating too much scar tissue in the heart?

The research carried out in rats confirmed that. The amount of peptide was clearly higher in those rats who had abnormal myocardial fibrosis than in those who did not. However, the result had to be tested in human beings. To do that, they did blood analysis and endomyocardial biopsies in hypertensive patients and found that in these patients myocardial collagen content was 4-5 times higher than in normotensive subjects and was closely correlated with serum levels of PIP.

Successful results

This new indicator, PIP substance, can successfully detect fibrosis in 80% of the cases. That is a great step forward considering the detection rate of the existing techniques. Now, in order to apply this technique, measures of PIP must be carried out in more patients. However, it has been proved that cardiac fibrosis is caused by hypertension and that it can be detected thanks to PIP peptide.

Moreover, analysing treatments to lower high blood pressure, they find out that some of the used medications which counteract the effects of a substance called angiotensin II, had a backward effect on fibrosis. This backward effect was observed in PIP substance aswell. Therefore, apart from indicating the presence of the disease and showing its severity, it may be used to assess the capability of antihipertensive medications to repare myocardial structure.

Future researches will be focused on physiological and pathological relationship between heart failure, fibrosis and high blood pressure. Then it may be possible to find prevention pathways of heart failure, which is widely prevalent in our age-increasing society.

Carton Eider | alphagalileo

More articles from Health and Medicine:

nachricht Candidate Ebola vaccine still effective when highly diluted, macaque study finds
21.10.2019 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Autism spectrum disorder risk linked to insufficient placental steroid
21.10.2019 | Children's National Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A cavity leads to a strong interaction between light and matter

Researchers have succeeded in creating an efficient quantum-mechanical light-matter interface using a microscopic cavity. Within this cavity, a single photon is emitted and absorbed up to 10 times by an artificial atom. This opens up new prospects for quantum technology, report physicists at the University of Basel and Ruhr-University Bochum in the journal Nature.

Quantum physics describes photons as light particles. Achieving an interaction between a single photon and a single atom is a huge challenge due to the tiny...

Im Focus: Solving the mystery of quantum light in thin layers

A very special kind of light is emitted by tungsten diselenide layers. The reason for this has been unclear. Now an explanation has been found at TU Wien (Vienna)

It is an exotic phenomenon that nobody was able to explain for years: when energy is supplied to a thin layer of the material tungsten diselenide, it begins to...

Im Focus: An ultrafast glimpse of the photochemistry of the atmosphere

Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols.

The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between radiation and matter. Light strikes particles...

Im Focus: Shaping nanoparticles for improved quantum information technology

Particles that are mere nanometers in size are at the forefront of scientific research today. They come in many different shapes: rods, spheres, cubes, vesicles, S-shaped worms and even donut-like rings. What makes them worthy of scientific study is that, being so tiny, they exhibit quantum mechanical properties not possible with larger objects.

Researchers at the Center for Nanoscale Materials (CNM), a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE's Argonne National...

Im Focus: Novel Material for Shipbuilding

A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.

The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

NEXUS 2020: Relationships Between Architecture and Mathematics

02.10.2019 | Event News

Optical Technologies: International Symposium „Future Optics“ in Hannover

19.09.2019 | Event News

 
Latest News

Kirigami inspires new method for wearable sensors

22.10.2019 | Materials Sciences

3D printing, bioinks create implantable blood vessels

22.10.2019 | Medical Engineering

Ionic channels in carbon electrodes for efficient electrochemical energy storage

22.10.2019 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>