Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug Derived From Sea Squirt Shows Potent Anti-tumour Activity

21.06.2007
The sea-squirt derived drug trabectedin (ecteinascidinin-743) shows anti-tumour activity in more than half of patients with a specific type of cancer, conclude authors of an Article published early Online and in the July edition of The Lancet Oncology.

Dr Federica Grosso, Sarcoma Unit, Instituto Nazionale Tumori, Milan, Italy, and colleagues in sarcoma centres in Boston, London, Lyon and Paris, did a retrospective study of the effect of trabectedin (derived from Ecteinascidia Turbinata) on patients with advanced pre-treated myxoid liposarcomas, a subtype of the liposarcoma group of cancers associated with specific chromosomal mutations.

They found that of 51 patients with myxoid liposarcomas given trabectedin as part of a compassionate-use programme, two saw their tumours disappear completely (complete response) while a further 24 saw the longest diameter of their tumour shrink by at least 30% (partial response), representing an overall response rate of 51%. Previous studies of trabectedin have shown response rates no higher than 20%. Of these 26 patients that responded, 23 had undergone radiological review of their tumours. The authors showed 17 of these 23 had also experienced reduced tumour density prior to the shrinkage or disappearance of their tumour.

In addition, the progression free-survival rate at six months was 88%, whereas previous studies in all soft tissue sarcomas have placed this figure closer to 20%. Median progression-free survival was 14 months.

The authors say: “If the results of this analysis are reproduced in ongoing prospective studies, myxoid sarcoma would represent a uniquely sensitive subgroup to trabectedin treatment in the heterogeneous family of soft-tissue sarcoma.”

Surgical removal is the mainstay of current treatment regimens for soft-tissue sarcoma, but despite this around half of patients develop distant metastases (secondary tumours) and die. Certain drugs, such as anthracyclines and ifosfamide, have shown response rates of 20-40%, but new drugs are needed.

The authors say that a compassionate-use programme of trabectedin treatment remains ongoing. They conclude: “This analysis has resulted in the initiation of two prospective studies to assess the role of trabectedin in the treatment of myxoid liposarcoma in the pre-operative and metastatic settings. Furthermore, the selective mechanism of action for trabectedin in this translocation-related sarcoma is being studied.”

Tony Kirby | alfa
Further information:
http://www.thelancet.com

More articles from Health and Medicine:

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>