Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Papillomavirus Vaccine Could Substantially Reduce Cervical Cancer Incidence

01.06.2007
Administering Human Papillomavirus Vaccine (HPV) to both sexually active women and those who have never had sex could substantially reduce the incidence of HPV related cervical cancer and precancers, conclude authors of an Article published in this week's edition of the Lancet.

Cervical cancer is the second leading cause of death from cancer in women worldwide, and is caused by infection with oncogenic (cancer causing) types of human papillomavirus. Around 500,000 new cases are diagnosed each year, 80% in developing countries, resulting in 250,000 deaths.

Dr Kevin Ault, Emory University School of Medicine, Atlanta, Georgia, USA and colleagues from around the world formed the Future II Study Group to investigate the efficacy of the vaccine.

For women who have never had sex, the vaccine was 99% effective in stopping cervical cancer (adenocarcinoma in situ), and pre-cancerous lesions.

When data from women who could have been exposed was included, the vaccine efficacy was 44%.

The researchers enrolled over 20,000 women aged 15-26 from the Americas, Europe and Asia-Pacific in the study. Some 9,000 of these were given the full vaccine; around 1,200 were given a component of the vaccine and the rest a placebo.

The women involved were recruited at university student health centres, urban clinics, advertisements and by word of mouth. Healthy women who were not pregnant, had no report of a previous abnormal pap smear, and had a lifetime history of less than four to five sex partners were eligible.

The authors say that further follow-up of large trials will be needed to establish how long the vaccine remains effective.

They conclude: "The results of this quadrivalent HPV vaccine programme provide strong evidence that implementation of HPV vaccination campaigns in pre-adolescent girls and young adult women will reduce rates of cervical cancer worldwide."

In an accompanying comment, Dr Maurie Markman, University of Texas M.D. Anderson Cancer Centre, Houston, Texas, USA, says a number of questions remain around HPV vaccination, including how long the vaccine will work, the best age at which to administer it, its cost and whether men and boys should also be vaccinated.

He concludes: "Other important hurdles need to be overcome, including: the absence of health-delivery infrastructure in many countries to permit comprehensive vaccination programmes, the politically-charged debate surrounding the issue of voluntary versus mandatory vaccination, the existence of unsubstantiated claims that HPV vaccination will encourage promiscuity, and the belief by some that vaccination is unnecessary in the developed world due to the effectiveness of cervical cancer screening strategies."

Tony Kirby | alfa
Further information:
http://www.thelancet.com
http://www.thelancet.com/webfiles/images/clusters/thelancet/press_office/papillomavirus.pdf

More articles from Health and Medicine:

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

nachricht Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Microscopic trampoline may help create networks of quantum computers

17.07.2018 | Information Technology

In borophene, boundaries are no barrier

17.07.2018 | Materials Sciences

The role of Sodium for the Enhancement of Solar Cells

17.07.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>