Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Difficult to give prognosis for early prostate cancer

04.04.2007
A common prognostic method for men diagnosed with localised prostate cancer turns out to be less effective than was previously thought, according to a new study by scientists at Karolinska Institutet.

The research team measured concentrations of PSA (Prostate-specific Antigen) in the blood of a group of cancer patients and then monitored the development of the disease.

The present study was conducted as part of the Scandinavian Prostate Cancer Group collaboration (project SPCG-4). The conclusion drawn by the research team is that the PSA value for the period after the diagnosis is insufficient as a method of distinguishing with any certainty the men who will develop a fatal cancer from those with a slower tumour growth. In general, men with localised prostate cancer have a good chance of surviving the disease, even without treatment. Yet many still undergo major surgery or radiotherapy, which carries the risk of impaired sexual function and urine incontinence.

"We have to find better methods of separating the patients who will develop malignant prostate cancer from those with a more benign disease," says PhD Katja Fall at Karolinska Institutet, one of the scientists behind the study. "This is important, not only to avoid unnecessary suffering, but also to make sure that hospital resources are directed towards the patients who need it most."

Previous research has shown that there is a link between how quickly the tumour will grow and the speed with which blood levels of PSA increase in the first stages of the cancer. To examine how accurately PSA development can predict the patient's prognosis, Dr Fall and her colleagues in the Scandinavian Prostate Cancer Group monitored 267 men from Sweden, Finland and Iceland diagnosed with prostate cancer between 1989 and 1999.

The PSA values measured in the first two years after diagnosis were used to describe the appearance of the early PSA curve for each patient. On follow-up at the end of 2003, 34 patients had died of prostate cancer and 18 had developed metastases but were still alive. Despite the fact that the PSA reading and the speed with which it increased during these first two years correlated with the development of aggressive prostate cancer, neither of these values was able to screen out with any certainty which patients would have needed intensive treatment from amongst those who would have managed just as well without.

Publication:
"Prostate-Specific Antigen Levels as a Predictor of Lethal Prostate Cancer"
Katja Fall, Hans Garmo, Ove Andrén, Anna Bill Axelson, Jan Adolfsson, Hans-Olov Adami, Jan-Erik Johansson, Lars Holmberg

Journal of the National Cancer Institute, Vol. 99, nr 7. 4 April 2007

For further information: Dr Katja Fall Tel: +46 (0)8-5248 6109 or +46 (0)709-221974 (mobile) Email: katja.fall@ki.se Press Officer Sabina Bossi Tel: +46 (0)8-524 860 66 Email: Sabina.bossi@ki.se

Katarina Sternudd | idw
Further information:
http://ki.se/ki/jsp/polopoly.jsp?d=130&a=30235&l=en

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>