Dementia involves a serious deterioration of mental function caused by some kind of dementia disease of the brain, of which Alzheimer’s is the most common. Although there is currently no cure for Alzheimer’s, it is possible to inhibit its development if the treatment is given early enough. However, with today’s diagnostics, it is very difficult to identify people with early Alzheimer’s.
A new doctoral thesis by Johanna Lind, Karolinska Institutet in Sweden, now shows that genetic mapping and brain imagery can be used to identify people who will develop dementia even before any clinical symptoms appear.
“This is a crucial step towards the better diagnosis of Alzheimer’s,” she says. “If the method is developed it can help us find the people who’d benefit most from treatment in good time.”
The method is based on the well-established fact that the APOE protein affects the risk of developing Alzheimer’s. APOE is a lipid-transporting protein important in, amongst other things, the repair of cerebral neurons. Roughly one person in five carries a genetically determined variant of APOE that is associated with an increased risk of Alzheimer’s.
In her study, Ms Lind was able to show that some of the people in this risk group had reduced parietal lobe activity, detectable using an MR camera, and that these same people were the ones who went on to suffer memory deterioration two to three years later.
“It’s surprisingly difficult to diagnose Alzheimer’s with any certainty, but things are made easier if you know who runs the greatest risk,” she says. “If genetic mapping, MRI and cognitive tests all suggest approaching Alzheimer’s, it might be an idea to start a course of treatment.”
Thesis: Memory, genes, and brain imaging - relating the APOE gene to brain function and structure
For further information, please contact:PhD Johanna Lind
Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine
UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
10.12.2018 | Event News
06.12.2018 | Event News
03.12.2018 | Event News
10.12.2018 | Life Sciences
10.12.2018 | Physics and Astronomy
10.12.2018 | Life Sciences