In a group of men undergoing coronary angiography, low baseline levels of RANTES (Regulated upon Activation, Normal T-cell Expressed, and Secreted), also known as CCL5, were shown to be an independent predictor of cardiac mortality.
RANTES is a chemokine produced by a variety of cell types including blood platelets that has been implicated in atherosclerosis. Chemokines are naturally occuring human proteins that signal white blood cells to move in a specific direction, such as to an infection site.
Erdal Cavusoglu, MD, assistant professor of medicine at SUNY Downstate, and colleagues measured baseline RANTES levels in 389 male patients at a Veterans Affairs medical center. The patients were followed prospectively for the occurrence of cardiac mortality and myocardial infarction (heart attack). Results showed that patients with the lowest level of RANTES had the lowest survival rate, and those with the highest levels had the highest survival rates. This was also true for the diabetic subset of patients in the study.
The authors propose several potential explanations for this somewhat paradoxical observation, including potential upregulation of the RANTES receptor, the CCR5 receptor, which is known for its proatherosclerotic properties. Alternatively, lower levels of RANTES may simply reflect greater deposition of RANTES on atherosclerotic arteries with less circulating levels available for measurement by routine ELISA testing.
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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20.08.2018 | Information Technology