Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Leptin – a potential link to colon cancer

10.01.2007
Tests on three human colon cancer cell lines showed that the fat-hormone ‘leptin’ may enhance the growth of colonic cancers.

This finding could show why obese people are at increased risk of colon cancer. It could also point to new modes of treating this type of cancer, finds research from the University of California, San Diego School of Medicine, published today in BJS.

Leptin is a hormone that is released from fat cells (adipocytes) – the more fat you have, the more leptin will be in your blood stream. This hormone plays an important role in regulating bodyweight and energy expenditure.

People who are obese have a two to three fold increased risk of developing colon cancer compared to similar normal-weight individuals. Research has also revealed that some colon cancer cells carry receptors for leptin.

The question is whether there is any evidence that these receptors could respond to increased levels of leptin that are caused by the obesity, and trigger the colon cancer cells to start dividing and growing. Now research shows that this may well be the case.

“These results may explain why obesity increases a person’s risk of colonic cancer, and the fact that we have shown how leptin stimulates these cells means that drug companies may be in a better position to develop new treatments against the disease,” says research co-author Dr Kim Barrett.

By culturing cancer cells in a laboratory, they found that leptin could stimulate growth. In two out of three cell lines, leptin also prevented the sort of programmed cell death (apoptosis) that allows for the orderly death of normal cells, but when reduced, can contribute to cancer.

The researchers then went on to reveal many of the signaling pathways that leptin affected in the cell. This showed that leptin does indeed interfere with many known intra-cellular systems that influence cancer cells.

Julia Lampam | alfa
Further information:
http://www.interscience.wiley.com/bjs

More articles from Health and Medicine:

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

New findings help to better calculate the oceans’ contribution to climate regulation

15.11.2018 | Life Sciences

Automated adhesive film placement and stringer integration for aircraft manufacture

15.11.2018 | Materials Sciences

Epoxy compound gets a graphene bump

14.11.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>