Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MIT implant could measure tumor growth, treatment

20.12.2006
A tiny implant now being developed at MIT could one day help doctors rapidly monitor the growth of tumors and the progress of chemotherapy in cancer patients.

The implant contains nanoparticles that can be designed to test for different substances, including metabolites such as glucose and oxygen that are associated with tumor growth. It can also track the effects of cancer drugs: Once inside a patient, the implant could reveal how much of a certain cancer drug has reached the tumor, helping doctors determine whether a treatment is working in a particular patient.

"You really want to have some sort of rapid measure of whether it's working or not, or whether you should go on to the next (drug)," said Michael Cima, the Sumitomo Electric Industries Professor of Engineering in the Department of Materials Science and Engineering, and the leader of the research team.

Such nanoparticles have been used before, but for the first time, the MIT researchers have encased the nanoparticles in a silicone delivery device, allowing them to remain in patients' bodies for an extended period of time. The device can be implanted directly into a tumor, allowing researchers to get a more direct look at what is happening in the tumor over time.

With blood testing, which is now commonly used to track chemotherapy progress, it's hard to tell if cancer drugs are reaching their intended targets, says Grace Kim, a graduate student in the Harvard-MIT Division of Health Sciences and Technology and one of the researchers working on the implant. That's because the system of blood vessels surrounding tumors is complicated, and you can't trust that drugs present in the blood have also reached the tumor, according to Kim.

The new technique, known as implanted magnetic sensing, makes use of detection nanoparticles composed of iron oxide and coated with a sugar called dextran. Antibodies specific to the target molecules are attached to the surface of the particles. When the target molecules are present, they bind to the particles and cause them to clump together. That clumping can be detected by MRI (magnetic resonance imaging).

The nanoparticles are trapped inside the silicone device, which is sealed off by a porous membrane. The membrane allows molecules smaller than 30 nm to get in, but the detection particles are too big to get out.

The device can be engineered to test for many things at the same time, leading Kim to offer a turkey-based analogy.

"When you're cooking a turkey, you can take the temperature with a thermometer," she said. "But with something like this, instead of just taking the temperature, you can find out about the moisture, the saltiness, and whether there's enough rosemary."

In addition to monitoring the presence of chemotherapy drugs, the device could also be used to check whether a tumor is growing or shrinking, or whether it has spread to other locations, by sensing the amount and location of tumor markers.

The next step for the research group is to start more extensive preclinical testing. They will be looking for a hormone, human chorionic gonadotropin (HCG), that can be considered a marker for cancer because it is produced by tumors but not normally found in healthy individuals (unless they are pregnant).

The researchers are now preparing a paper on the work and have presented their findings at recent meetings of the European Cancer Society and the American Institute of Chemical Engineers.

Other MIT researchers involved in the project are Karen Daniel, a graduate student in chemical engineering, Christophoros Vassiliou, a graduate student in electrical engineering and computer science, and Noel Elman, a postdoctoral associate in the Materials Processing Center. Lee Josephson, an associate professor at the Center for Molecular Imaging Research at Massachusetts General Hospital, is also contributing to the project.

This work is funded by the National Cancer Institute through the MIT-Harvard Center of Cancer Nanotechnology Excellence.

Elizabeth A. Thomson | MIT News Office
Further information:
http://www.mit.edu

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>