"These data are very concerning because hormonal therapy for breast cancer is one of the most effective treatments in all of oncology," said Ann Partridge, MD, MPH, the study's lead author and a breast cancer specialist at Dana-Farber. "Women may be compromising their care, and ultimately their survival, if they do not take these medications as recommended."
Partridge and her colleagues analyzed claims data from three large commercial health plan systems to gauge treatment compliance of more than 7,000 women with early stage-breast cancer who, in addition to their regular treatment, began taking anastrozole.
Anastrozole is part of a new class of drugs, called aromatase inhibitors, that reduces the production of the hormone estrogen by blocking aromatase, an enzyme that converts the hormone androgen into estrogen. Studies have shown that lowering estrogen levels in post-menopausal women with hormone receptor-positive breast cancer can reduce their risk of disease recurrence.
In one of the health plans analyzed, the researchers found that 85 percent (1,275) of the women were still filling their prescriptions a year after anastrozole was first prescribed, but not everyone was doing so on a regular basis. The researchers also looked at the prescription filling habits of the 1,111 women who had been enrolled in the health plan for 12 consecutive months. They determined that, due to inconsistent refills, 19 percent of the women (211) had access to the drug less than 80 percent of the 12-month period after they first filled an anastrozole prescription. These women were considered to be non-adherent to the treatment.
"This study confirms that even patients with cancer may be non-adherent to their treatment," said Partridge, who is also an assistant professor of medicine at Harvard Medical School. "Non-adherence is a very complex issue, and the reasons that a patient may not take her medication as directed can include fear of or the experience of side effects, cost of treatment, and negative health beliefs, like the treatment will not help."
Bill Schaller | EurekAlert!
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology