Oxford Gene Technology (OGT), St George’s University of London and St George’s Healthcare NHS Trust are pleased to announce the signing of a collaboration agreement to develop a cost-effective single platform microarray to diagnose multiple sexually transmitted infections (STIs).
The collaboration between OGT and St George’s aims to develop a diagnostic test with the capacity to detect the DNA of many sexually transmitted pathogens in one specimen from infected people.
The microarray test aims for more comprehensive and accurate diagnoses with accurate same-day results. Ultimately, the array technology lends itself to the development of point-of-care testing for multiple STIs combined with the highest standards of accuracy. The STI diagnostic microarray is a timely investment in new gene technologies that directly address the emerging crisis of STIs in the UK, highlighted by the recent report of the Health Protection Agency (2006).
Dr Tariq Sadiq, Senior Lecturer and Consultant Genito Urinary Physician at St George’s, said on behalf of the University and NHS Trust “The incidence of STI continues to rise and is challenging our ability to provide care for our patients, directly costing the NHS in excess of £1 billion a year. As more responsibility for this care falls on settings such as GP practices, community based sexual health care providers and even high street pharmacies, concern exists for the need to maintain high standards of diagnostic accuracy while also recognising the increasing role of many infections not traditionally tested for. If successful, we think the microarray may be an important tool in the attempts to reduce the burden of STIs and their transmission”
Diagnostic DNA microarrays or ‘gene chips’ have been pioneered by the research team of Professor Philip Butcher, of St George’s, University of London, for bacterial and viral pathogen detection, exploiting expertise in bacterial microarrays built up by the Wellcome Trust funded B?G@S project (http://www.bugs.sgul.ac.uk).
In partnership with St George’s clinical and microbiology expertise, OGT will design and develop the high quality optimised 60mer oligonucleotide microarray using its ink jet in-situ synthesis (IJISS) platform and will also investigate the use of its Multi Sample Array (MSA) format enabling the parallel analysis of multiple samples. This will aim to reduce the cost per sample and provide a rapid diagnostic result.
Dr John Anson, Research and Development Director at OGT said: “OGT’s microarray technologies will provide a nucleic acid based tool which, coupled with PCR amplification, is aimed at producing a diagnostic test to improve the detection range, accuracy and the speed of STI diagnosis to meet clinician’s needs.”
The project will be jointly funded by the Heptagon Proof of Concept Fund and OGT and will last a year in the first instance. By then end of this period, the team hope to have a prototype which will then be validated using clinical samples.
To access a copy of the HPA report, “A complex picture: HIV & other sexually transmitted infections in the United Kingdom: 2006” http://www.hpa.org.uk/publications/2006/hiv_sti_2006/default.htm
For further information, please contact:At Oxford Gene Technology:
Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine
UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
10.12.2018 | Event News
06.12.2018 | Event News
03.12.2018 | Event News
10.12.2018 | Life Sciences
10.12.2018 | Physics and Astronomy
10.12.2018 | Life Sciences