A team of experts from across the Netherlands studied the medical profiles of 4,245 adults who had received kidney transplants, using data from the Netherlands Organ Transplantation Registry.
In 2067 cases there was sufficient information to calculate their Body Mass Index (BMI) – based on their weight and height - at the time of their kidney transplant.
They discovered that six per cent of patients with a BMI of more than 30 died in the first year after transplant, compared with three per cent of patients with a BMI of less than 30.
By year five, the difference was even greater, with an 81 per cent survival rate for the obese patients and an 89 per cent survival rate for patients who were not obese.
The same pattern emerged when they looked at the success of the transplant itself.
A year after the transplant was carried out, 14 per cent of obese patients had experienced a transplant failure, compared with eight per cent of non obese patients.
After five years, 71 per cent of obese patients still had a successfully transplanted kidney, compared with 80 per cent of the patients with a lower BMI.
Obese patients were more likely suffer transplant failure through infection or permanent non-functioning, but the numbers for obese and non-obese patients were both fairly low.
There were no significant differences between the two groups when it came to why patients died, but there was a trend for obese patients to suffer more infections and fatal heart conditions.
Obese patients in the study group also tended to be older and were more likely to be female
“The prevalence of obesity in patients with end-stage renal disease is increasingly rapidly” says lead researcher Dr Jeroen Aalten from the Department of Nephrology at the University Medical Center in Nijmegen.
“It’s estimated that 60 per cent of renal transplant candidates in the United States and 10 per cent in the Netherlands are obese or overweight.
“These figures have been rising consistently in recent years. This could be due to a general rise in obesity worldwide, but we can’t rule out that it may have been affected by changes in inclusion criteria for kidney transplants.”
The study – which was carried out by Nephrology specialists from seven university hospitals across the Netherlands – concluded that there is a significant relationship between obesity and increased transplant failure or death.
The authors acknowledge that there has been considerable debate about whether obese patients are suitable transplant candidates.
But they also point out that while obesity is preventable and fundamentally curable, compared to age and diabetes, experience shows that it can be very difficult for people with end-stage renal disease to lose weight.
“Our conclusion is that it’s not fair to deny obese patients the chance of a kidney transplant as they still do better after a transplant than on dialysis” says Dr Aalten.
“However we shouldn’t disregard the increased risk for obese patients after transplantation and we also need to bear in mind that it is important to give scarce resources to patients with the lowest risk.
“It is very important that patients facing kidney transplant are fully informed about the risks that they face and are encouraged to lose weight wherever possible.”
Annette Whibley | alfa
Live probiotics can re-balance the gut microbiome and modify immune system response
20.11.2018 | Symprove
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.
Electric diodes are essential electronic components that conduct electricity in one direction but prevent conduction in the opposite one. They are found at the...
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
21.11.2018 | Life Sciences
21.11.2018 | Power and Electrical Engineering
21.11.2018 | Life Sciences