Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Psoriasis: skin symptoms may be just the tip of the iceberg

25.10.2006
International Psoriasis Council issues a ‘call to action’ following a collaborative Consensus Meeting to review implications for clinical practice

World Psoriasis Day will have a more poignant focus this year as the International Psoriasis Council (IPC) issues a ‘call to action’ to medical experts to elevate psoriasis on the public health agenda by undertaking a more thorough therapeutic approach. Recommendations include the need to review current guidelines to ensure a more holistic approach to the management of psoriasis, taking into account the many potential co-morbidities, to prevent this significant health burden escalating. It is essential that physicians are vigilant about monitoring patients for signs of co-morbid conditions and are educated on all the therapeutic options available.

These recommendations come following a collaborative Consensus Meeting convened by the IPC held at the 15th European Academy of Dermatology and Venereology (EADV) Congress earlier this month. Multi-disciplinary medical professionals from around the globe reviewed the inflammatory nature of psoriasis and how it might be linked to co-morbid conditions such as obesity, cardiovascular disease (including hypertension, and myocardial infarction), type II diabetes and liver disease.

Dr Bruce Strober, assistant professor in the department of dermatology at New York University School of Medicine, commented, “Mounting data suggest that psoriasis is a component of an inflammatory state that nurtures significant co-morbidities. It is likely that in some patients both psoriasis and obesity are co-dependent manifestations of an underlying dysfunctional pathophysiologic state. It is important that the overall management of psoriasis is significantly improved to ensure that patients are diagnosed early, appropriately treated and regularly monitored for signs of co-morbidity.”

Among the data presented at the meeting was a statistical study of over 10,000 patients in clinical trials conducted over the past 5 years, showing that psoriasis patients are more likely to have body mass index (BMI) measurements in the overweight and obese ranges than members of the general population. Building on this point, Dr Gerald Krueger of the University of Utah presented a study which indicated that psoriasis and obesity are endpoints of a shared etiology in which one may promote the other.

Important data indicating an increased risk of cardiovascular disease was presented for the first time at the meeting. A large study by Dr Joel Gelfand of the University of Pennsylvania, recently published in the Journal of the American Medical Association, highlighted that psoriasis may be an independent risk factor for heart attack, particularly in young individuals with severe disease. Patients in their 40s with severe psoriasis were more than twice as likely to suffer a heart attack than people without the skin disease. Dr Gelfand’s findings also shed light on potential health risks for overweight psoriasis patients. These data are supported by a case-control study presented at the meeting showing that twice the number of psoriasis patients (60%) had coronary artery calcification than non-psoriasis patients (30%).

Other studies presented at the meeting indicated that patients suffer from their skin disease much more than previously understood. One trial showed that almost half of 1,000 psoriasis patients tested were likely to be clinically depressed, and another demonstrated an increased tendency to use alcohol and tobacco among psoriasis patients.

The consensus group agreed there is overwhelmingly sufficient data supporting the linkage of psoriasis to increased co-morbid risk and to mandate furture investigations funded by both government and industry. Professor Wolfram Sterry, a board member of IPC who chaired the consensus meeting concluded, “Psoriasis is a serious condition in its own right that is exacerbated by its association with co-morbidities. It is essential that physicians understand the severity of the disease and all its manifestations and integrate therapy in a way that provides a treatment that is as broad as possible to cover all the ongoing pathogenetic events.”

Asked about the outlook for the future, Dr Menter, President of IPC is optimistic: “The hope is that now that we understand better the systemic inflammatory nature of psoriasis, we can work closely with our colleagues in medicine and research to improve the general health of our psoriasis patients by using the full spectrum of medications, including the new biologic agents.”

Drs. Sterry, Menter, and Strober are currently working on a paper that will summarise the consensus of the IPC meeting, investigate the relationship between psoriasis and co-morbidities, discuss important areas for research on these issues, and issue recommendations for clinical management of psoriasis patients at risk of developing co-morbid conditions. For now it is important that everyone touched by psoriasis recognises the severity of the condition and the profound lifelong impact it has on health.

Maja Haglund | alfa
Further information:
http://www.ketchum.com
http://www.psoriasiscouncil.org

More articles from Health and Medicine:

nachricht Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>