Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Role of Folate and Homocysteine in Alzheimer's Disease Examined

28.09.2006
There may be a connection between dietary deficiencies and Alzheimer's disease.

In a special issue of the Journal of Alzheimer's Disease published this month, ten contributions from worldwide experts in the field examine possible linkages between folate and homocysteine and Alzheimer's disease.

In the lead article Guest Editor Thomas Shea, Professor and Director of the Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts Lowell, suggests “Alzheimer’s disease has a multifactoral etiology, encompassing genetic and nutritional risk factors, and no single risk factor can account for all cases.…A genetic predisposition may remain latent pending an age-related critical decline in nutrition. This has confounded the linkage of nutrition to Alzheimer’s disease, since contributing nutritional deficiencies may remain undetected, and, even if considered, may not receive sufficient attention if they are benign in isolation.”

Andrew McCaddon from the Wales College of Medicine contributes some historical perspective on homocysteine and folate levels and the development of dementia, including some discussion of the potential for reversing such declines.

Aron M. Troen and colleagues from Tufts University write of their studies of mice fed diets to create excess homocysteine levels and then tested for cognitive functions. Sudha Seshadri discusses whether elevated homocysteine levels is a risk factor for dementia or merely a risk marker for some underlying process. Amy Chan and Thomas B. Shea then examine the connection between dietary deficiencies of folate and Vitamin E and the development of neurofibrillary tangles of tau protein, a hallmark of Alzheimer's disease.

Moving on to possible therapies, Sigfrido Scarpa and colleagues at the University of Rome investigated S-adenosylmethionine (SAM) metabolism in cell cultures, which might be used to interfere with amyloid-ß overproduction, another characteristic of AD. In a second contribution from that institution, Rosaria A. Cavallaro and co-workers looked at whether SAM administration influences gene expression in the brain.

Flaubert Tchantchou of the University of Maryland School of Pharmacy discusses the various metabolic processes involved in homocysteine regulation and the various consequences of folate deficiency.

Folate is one of the B vitamins. Martha Clare Morris and colleagues at the Rush University Medical Center expand on the possible role of all of the B vitamins in cognitive decline and comment on the potential benefits and harms of vitamin supplementation. In another contribution, Morris and coworkers report on a prospective cohort study of 1041 patients where dietary folate, B-12 and B-6 levels were not associated with the development of Alzheimer's disease.

SPECIAL ISSUE: FOLATE AND HOMOCYSTEINE IN ALZHEIMERS DISEASE
Guest Editor: Thomas B. Shea, University of Massachusetts Lowell
Journal of Alzheimer's Disease, Volume 9, Issue 4 (September 2006)
TABLE OF CONTENTS
Folate, the methionine cycle, and Alzheimer's disease
Thomas B. Shea
Homocysteine and cognition - A historical perspective
Andrew McCaddon
The cognitive impact of nutritional homocysteinemia in Apolipoprotein-E deficient mice

Aron M. Troen, Barbara Shukitt-Hale, Wei-Hsun Chao, Bina Albuquerque, Donald E. Smith, Jacob Selhub, Jacob Rosenberg

Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease?

Sudha Seshadri

Dietary and genetically-induced oxidative stress alter tau phosphorylation: Influence of folate and apolipoprotein E deficiency

Amy Chan and Thomas B. Shea

Gene silencing through methylation: An epigenetic intervention on Alzheimer disease

Sigfrido Scarpa, Rosaria A. Cavallaro, Fabrizio D'Anselmi, Andrea Fuso

The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis

Rosaria A. Cavallaro, Andrea Fuso, Fabrizio D'Anselmi, Laura Seminara, Sigfrido Scarpa

Homocysteine metabolism and various consequences of folate deficiency
Flaubert Tchantchou
Thoughts on B-vitamins and dementia
Martha Clare Morris, Julie A. Schneider, Christine C. Tangney
Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease

Martha Clare Morris, Denis A. Evans, Julie A. Schneider, Christine C. Tangney, Julia L. Bienias, Neelum T. Aggarwal

Selected Abstracts From the "Wellness For Persons With Dementia" Symposium
Nancy B. Emerson Lombardo
Discussion
Alzheimer Research Forum Live Discussion: Lost in Translation? Charting the Course in Preclinical Therapeutic Development

Astrid Engelen | alfa
Further information:
http://www.j-alz.com/issues/9/vol9-4.html

More articles from Health and Medicine:

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

nachricht Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

'Building up' stretchable electronics to be as multipurpose as your smartphone

14.08.2018 | Information Technology

During HIV infection, antibody can block B cells from fighting pathogens

14.08.2018 | Life Sciences

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>