Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Regular paracetamol use could reduce ovarian cancer risk by almost a third

06.07.2006
Using paracetamol regularly could reduce the risk of ovarian cancer by almost a third, according to a detailed analysis in the July issue of British Journal of Clinical Pharmacology.

A research team from Athens University found that the risk fell by up to 30 per cent when they analysed the results of major studies carried out on more than 746,000 women over a six-year period.

4,405 of the women in the eight major studies – from the USA, UK and Denmark – had ovarian cancer.

The team looked at all studies covering paracetamol and ovarian cancer from 1966 to 2004. These were then scrutinised using sophisticated meta-analysis techniques.

“Meta-analysis involves doing a large amount of research into what has been published, summarising the results and combining them using statistical methods” explains lead researcher Dr Stefanos Bonovas from the Greek Ministry of Health. “Analysing a wide range studies can often throw new light on a problem and raise new research questions.

“In this case our analysis of eight major studies – covering nearly three-quarters of a million women - revealed a strong correlation between paracetamol use and a reduced risk of ovarian cancer.”

Seven of the studies looked at the links between paracetamol use and the incidence of ovarian cancer and the largest study looked at the link between paracetamol use and ovarian cancer deaths.

The researchers used a working definition of “regular use” as the highest frequency of drug use reported in the individual studies. This definition varied slightly between studies. In the largest study – which covered more than a third of the women diagnosed with ovarian cancer – it was defined as more than 30 tablets in the month before the study started.

“Ovarian cancer remains the most fatal gynaecological malignancy” says Dr Bonovas. “Its high mortality rate – mainly due to a combination of ineffective screening and the limited success of therapies for advanced disease - makes ovarian cancer a major health concern.

“Strategies that focus on prevention may therefore provide the most rational approach for reducing deaths from this form of cancer.

“Because paracetamol is so widely used, a link with a decreased risk of ovarian cancer could have important public health implications.”

The authors believe that further research among women with a high risk of developing ovarian cancer would provide further clues to the drug’s protective qualities.

“The risks of long-term paracetamol use - including liver and chronic kidney failure – may outweigh the potential benefits of preventing ovarian cancer in low-risk cases” concludes Dr Bonovas.

”However we believe that a randomised trial in women with a high risk of developing the disease might be appropriate. Further research is also needed into how this protective mechanism actually works.

The authors stress that they are not suggesting that women adopt this possible method of risk prevention at this stage.

“But we do feel that our study highlights the need for further research into this highly important link between a simple over-the-counter medicine and a very aggressive form of cancer” says Dr Bonovas.

Dr Bonovas works for the Department of Epidemiological Surveillance and Intervention at the Greek Ministry of Health’s Hellenic Centre for Infectious Diseases Control and carries out his research at Athens University.

This study was carried out in association with University researcher Dr Kalitsa Filioussi, under the supervision of Dr Nikolaos M Sitaras, Associate Professor of Medicine in the Department of Pharmacology.

Annette Whibley | alfa
Further information:
http://www.blackwellpublishing.com/bjcp

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>