"Three to six weeks after the minimally invasive procedure, kidney function was roughly equal to what is typically achieved with major surgery," said Matthew S. Edwards, M.D., M.S., assistant professor of surgery and lead author. "We hope this will lead to a better way to do angioplasty and stenting by preventing damage to the kidneys and improving kidney function."
The study suggests that the key to success was using suction to prevent the plaque and other material that make up blockages from reaching the kidneys and causing damage. In previous studies of angioplasty without a suction or filtering device, results have been inconsistent.
Angioplasty involves inserting a balloon-like device into the vessel to crush fatty deposits that are blocking blood flow. In many cases, a stent, or scaffold-like device, is inserted to help keep the vessel open. In this study, Edwards used what is called a "distal embolic protection system" that consisted of a balloon system to temporarily block the vessel and a suction system to remove the bits of crushed material that made up the blockage. (Undesirable particles and air bubbles in the blood are known generally as "emboli.")
The study involved 32 patients with a mean age of 70 years. Kidney function improved in 50 percent of the procedures and worsened in none. The narrowed arteries were reopened in 100 percent of cases and mean blood pressure was reduced from 176/81 mm Hg to 158/76 mm Hg.
"These data suggest that distal embolic protection systems may prevent damage to the kidneys during angioplasty and stenting and warrant further investigation," said Edwards.
Surgery to restore blood flow to the kidneys is a common procedure, said Edwards. Previous research at Wake Forest found that about 7 percent of healthy older Americans have renal artery stenosis, or narrowing in the main artery leading to the kidneys, and about 40,000 of the 3.5 million Americans who have the condition will require surgery.
The condition is most common in people with severe, difficult to control high blood pressure. Over time, the hypertension can lead to the narrowed vessels. Conversely, in a small number of cases, it is narrowed vessels to the kidneys that cause hypertension. Surgery may be called for when patients have abnormal kidney function because of reduced blood flow to the organs, or when the uncontrolled hypertension has led to heart failure or blockages in other vessels in the body, such as those leading to the heart.
Without successful surgery to open the kidney vessels and improve organ function, patients have a much greater risk of adverse cardiovascular events, dialysis dependence and death, Edwards said. He plans further studies, in larger groups of patients, of the less invasive procedure for restoring blood flow.
Karen Richardson | EurekAlert!
New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute
Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences