Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chromosomal abnormalities in sperm higher after vasectomy reversal

21.06.2006
Prague, Czech Republic: Men who have had a vasectomy reversed have a very much greater rate of chromosomal abnormalities in their sperm than do normal fertile men, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology today (Wednesday 21 June 2006). Professor Nares Sukchareon, of the Department of Obstetrics and Gynaecology, Chulalongkorn University, Bangkok, Thailand, said that doctors needed to be aware of this problem and monitor carefully children born as a result, particularly if assisted reproductive technology (ART) was involved.

Professor Sukchareon and his team had been studying men with obstructive azoospermia, a condition where sperm are created but cannot be mixed with the ejaculatory fluid due to a physical obstruction (such as a vasectomy). He found that they had high rates of chromosomal aneuploidy (where an abnormal number of specific chromosomes or chromosome sets exist within the nucleus of the cell) and diploidy (containing two sets of chromosomes – unlike most cells in the body, the sex cells should only contain one set of chromosomes.

“The rate of abnormality was about 10 times higher than the aneuploidy and diploidy rate in normal fertile men”, said Professor Sukchareon. “This raised a lot of questions, so we decided to study the rates of these abnormalities in ejaculated sperm after vasectomy reversal. If these sperm continued to have a high rate of aneuploidy and diploidy, we would know that obstruction by vasectomy must affect spermatogenesis in the longer term.”

The scientists found a significant correlation between the duration of the obstruction in post vasectomy-reversal men and the number of abnormal sperm, and also between the time interval after vasectomy reversal and the total sex chromosome aneuploidy rate – i.e. the long ago the reversal the better the chances of producing normal sperm.

“This study raises a lot of questions”, said Professor Sukcharoen. “Is the abnormal spermatogenesis reversible, and if so, how long will it take before things get back to normal? Perhaps more importantly, will babies born after vasectomy reversal – either conceived naturally or by ART – have problems themselves?”

To date there have been no studies looking at these questions, he said, and his team are beginning the follow-up research. “We are collecting sperm during vasectomy reversal operations and will compare the aneuploidy rate of these and of the sperm we will collect each month in the future from the same men. This will help us understand what the dangers are. But in the meantime, I think that doctors need to be very aware of the possibility that babies born after vasectomy reversal may have problems.”

Their findings may not affect babies conceived naturally after such a procedure, says Professor Sukchareon, since the female genital tract may select the best sperm for fertilisation. “But this is still uncertain, and until we know more it would probably be safer to freeze ejaculated sperm before vasectomy. We need a lot more evidence and research on this issue before we can be certain of avoiding the dangers.”

Mary Rice | alfa
Further information:
http://www.eshre.com

More articles from Health and Medicine:

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>