Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood compatibility – it’s all in the genes!

31.05.2006


In most developed countries safe blood transfusion is taken for granted. But blood grouping is a complex business, and not all blood groups are compatible. In order to check for compatibility, two cross-matching tests are carried out prior to transfusion - but these tests are based on technology that has not changed since the early days of blood transfusions.



Now a consortium called Bloodgen, led by the University of the West of England (UWE), Bristol, is nearing the end of a three-year project that aims to use genotyping to improve patient safety and blood transfusion compatibility. The project will include the launch of a CE-marked commercial product Bloodchip which will be sold to Blood Services worldwide. A Research TV film on the project, entitled ‘Compatibility – it’s all in the genes’ – can be seen at http://research-tv.warwick.ac.uk/stories/health/bloodgen/

Currently, the two blood groups are tested for routinely ABO and Rh (Rhesus). However there are 29 different blood group systems Not all blood groups are compatible and mixing incompatible groups can put some people at risk. Bloodchip tests for 9 of these systems, which includes all clinically relevant blood groups.


The blood group to which people belong depends on the combination of antigens built into their DNA and antibodies to antigens they have previously been exposed to. The genotyping test extracts DNA from blood and uses a gene chip, a small microscope slide capable of performing up to 300 reactions, to compare donated blood with that of a potential recipient.

Professor Neil Avent, director of UWE’s Centre for Research in Biomedicine and leader of the project said:

“Blood grouping at the moment uses antibodies that interact with proteins on the surface of cells. Genotyping is looking at the genes: our research looks at the blood group specific genes which vary from one individual to another. This is certainly a safer means of testing blood because of its comprehensiveness. The chip will embrace all blood groups that are clinically significant and we’ll be able to have those tested on a routine basis.

“The ultimate goal is that a new technology will come in and replace techniques that have been around for 100 years or so. Genotyping is incredibly accurate and could be used for a wide range of routine testing of patients in the near future.”

Lesley Drake | alfa
Further information:
http://www.uwe.ac.uk

More articles from Health and Medicine:

nachricht Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>