Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Statins prove life-saving in patients with acute coronary syndromes

12.05.2006


Analysis finds statins succeed where it matters most—in improving survival



Patients who begin aggressive statin therapy while in the hospital for acute coronary syndromes (ACS) have a significantly greater chance of long-term survival, according to an analysis reported at the Society for Cardiovascular Angiography and Interventions (SCAI) 29th Annual Scientific Sessions in Chicago, May 10–13. (Time of presentation: Thursday, May 11, 11:33 a.m., Central Time)

By combining data from nine randomized clinical trials and evaluating clinical outcomes individually rather than in combination, the analysis was able to put a sharper focus on the benefits of early statin therapy.


"We found that there was a benefit in what matters most--survival," said Anthony Bavry, MD, a fellow in cardiovascular medicine at the Cleveland Clinic Foundation in Cleveland, OH.

The study involved data from more than 16,000 patients admitted to the hospital with ACS, a term that encompasses both unstable chest pain, or angina, and a particular form of heart attack. In each of the original studies, patients were randomly assigned to maximal-dose statin therapy during the hospital stay or to a more conservative approach that consisted of low-dose statin therapy or placebo.

Statins are primarily used to lower cholesterol levels in the blood, but they have other effects as well, including the ability to reduce inflammation in the arteries.

Dr. Bavry and his colleagues found that early, aggressive statin therapy reduced the risk of death by 22 percent and the risk of cardiovascular death by 25 percent, over a follow-up that averaged 15 months. Further analysis showed that for every 111 patients who were treated with early statin therapy, one life could be saved.

In addition, early statin therapy reduced the risk of another episode of unstable angina by 17 percent and the need to open a blocked coronary artery with a catheter-based procedure or coronary bypass surgery by 9 percent.

The improvement in survival was noticeable early on but became statistically certain only after six months of statin therapy. "The benefits keep accruing," Dr. Bavry said. "Once a patient has acute coronary syndrome, there may not be a safe time to discontinue this medication."

Kathy Boyd David | EurekAlert!
Further information:
http://www.scai.org

More articles from Health and Medicine:

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

nachricht Pain: Perception and motor impulses arise in the brain independently of one another
12.12.2018 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Foxes in the city: citizen science helps researchers to study urban wildlife

14.12.2018 | Ecology, The Environment and Conservation

Magic number colloidal clusters

13.12.2018 | Life Sciences

UNLV study unlocks clues to how planets form

13.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>