Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Camelford Resident Died of Rare Form of an Aluminium-Associated Early Onset Alzheimer’s-like Disease

21.04.2006


The first neuropathological examination of a Camelford resident who, in 1988, was exposed to extremely high concentrations of aluminium in drinking water and died of an unknown neurological condition, has revealed a rare form of an early onset Alzheimer’s-like disease.



Analysis of affected brain tissue revealed extremely high concentrations of aluminium - levels similar to those observed previously in aluminium-induced brain diseases, including dialysis-associated encephalopathy (dialysis dementia).

Dr Christopher Exley, of the Birchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories at Keele University in Staffordshire, and Professor Margaret M Esiri, of the Departments of Clinical Neurology, University of Oxford, and Neuropathology, Oxford Radcliffe NHS Trust, Oxford, found no evidence of genetic mutations normally associated with early-onset forms of Alzheimer’s Disease. The neuropathology was characterised by severe deposition of beta-amyloid in cortical and leptomeningeal blood vessels in the brain.


This is the first discovery of an association between aluminium and any form of presenile dementia and the first time that the aluminium status of an individual has been linked with APOE, the major risk factor in sporadic Alzheimer’s Disease.

It is concluded that there is no likelihood that these levels of aluminium could appear in the brain by chance and, therefore, the previous exposure to aluminium in 1988 may have been a contributing factor. It is recommended that further neuropathological examinations are carried out on similar neurological conditions both from within and without the exposed population of Camelford.

The research is published in the Journal for Neurology, Neurosurgery and Psychiatry and will be available Online First (http://jnnp.bmjjournals.com/onlinefirst.dtl) from Thursday 20th April.

The results of this first neuropathological examination of an individual, who was exposed to the contaminated water in 1988 and has since died, opposes the conclusions of the most recent draft report (January 2005) of a DH Enquiry into Camelford ( http://www.advisorybodies.doh.gov.uk/cotnonfood/lowermoor.htm), which concluded that no long term health effects of the incident were expected. This report, which has been heavily criticised (see for example, http://bmj.bmjjournals.com/cgi/eletters/330/7486/275-a?ck=nck), has yet to be published and would need to be re-written to take the latest findings into account.

Thousands of homes were affected in 1988 when the water supply in Camelford, Cornwall, was contaminated with a toxic mix of aluminium sulphate and metals. A relief driver accidentally tipped 20 tonnes of aluminium sulphate into the wrong tank. The chemicals, used to remove solid particles from cloudy water, went directly into the mains supply at Lowermoor Water Treatment Works and affected up to 20,000 people.

Dr Chris Exley | alfa
Further information:
http://jnnp.bmjjournals.com/onlinefirst.dtl

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First diode for magnetic fields

Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.

Electric diodes are essential electronic components that conduct electricity in one direction but prevent conduction in the opposite one. They are found at the...

Im Focus: Nonstop Tranport of Cargo in Nanomachines

Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.

Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

Helping to Transport Proteins Inside the Cell

21.11.2018 | Life Sciences

Meta-surface corrects for chromatic aberrations across all kinds of lenses

21.11.2018 | Power and Electrical Engineering

Removing toxic mercury from contaminated water

21.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>