Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Senegal: trial of intermittent malaria treatment in children leads to 86% reduction in cases

24.02.2006


A team of researchers from the London School of Hygiene & Tropical Medicine, working in partnership with colleagues from Senegal, has found that intermittent preventive malaria treatment of children under five has a dramatic impact on malaria frequency.



In a randomised, placebo-controlled trial, 1,136 children aged between two months and five years received either intermittent preventive treatment, consisting of one dose of artesunate plus one dose of sulfadoxine-pyrimethamine, or two placebos. The preventative treatments were carried out on three occasions during the malaria transmission season, in a health-care centre in Niakhar, a rural area of Senegal.

During thirteen weeks of follow up, the intervention led to an 86% reduction in the frequency of clinical episodes of malaria. The incidence of malaria in children with active drugs was 308 episodes per 1,000 person-years at risk, whereas in controls it was 2,250 episodes per 1,000 person-years at risk. The preventative treatment was safe and did not result in children who had received it experiencing more malaria episodes the following year.


According to the World Health Organisation, 90% of deaths from malaria occur in Africa, mostly in children under 5 years of age. In Senegal, the yearly mortality rate from malaria in children has increased substantially since the beginning of the 1990s, due in large part to growing resistance to standard malaria treatments. In addition to developing new malaria drugs there is a need to develop new ways of preventing the disease.

Dr Badara Cisse, a PhD student of the London School of Hygiene & Tropical Medicine (LSHTM) who is now based at the University of Dakar, Senegal, was principal investigator of the trial, and first author of the study, which appears in the February 25 issue of The Lancet. He is a one of 33 research degree students, mostly from malaria-endemic countries, to have been trained under the Capacity Development component of the Gates Malaria Partnership, which aims to strengthen research capability in the field of malaria.

Dr Cisse comments: ‘Seasonal intermittent preventive treatment is simple, cheap and dramatic in its impact on malaria in children under five in areas of seasonal malarial transmission. The results of this trial are very encouraging, but we do need to carry out further studies into whether the treatment can be delivered on a bigger scale. If we are to ensure higher rates of coverage, then we need to bring the whole community on board. There is also the question of what the effect might be on drug resistance, which needs to be further explored’.

Lindsay Wright | alfa
Further information:
http://www.lshtm.ac.uk

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Quantum bugs, meet your new swatter

20.08.2018 | Information Technology

A novel synthetic antibody enables conditional “protein knockdown” in vertebrates

20.08.2018 | Life Sciences

Metamolds: Molding a mold

20.08.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>