Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antioxidant supplementation not associated with decreased risk of prostate cancer

15.02.2006


Intakes of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among men in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, according to a study in the February 15 issue of the Journal of the National Cancer Institute . The study did find that vitamin E and beta-carotene supplementation may be associated with reduced prostate cancer risk in certain population subgroups.



Research suggests that micronutrients such as vitamin E, vitamin C, and carotenoids may play a role in preventing cancer development because of their ability to combat free radicals, agents that can damage cellular DNA, lipid membranes, and proteins. In many studies, vitamin E has been associated with a reduced risk of prostate cancer, and beta-carotene has been associated with increased lung cancer risk in previous studies. However, no studies have examined associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.

Richard B. Hayes, Ph.D., at the National Cancer Institute, and colleagues assessed the risk of prostate cancer for 29,361 men ages 55 to 74 enrolled in the PLCO Cancer Screening Trial, based on their daily intake of beta-carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.


The authors found that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta-carotene was not associated with prostate cancer incidence in this group of PLCO trial participants. However, certain micronutrients were associated with prostate cancer risk in specific subgroups of men. For current or recent smokers, high-dose, long-duration vitamin E supplementation was associated with a reduced risk of advanced prostate cancer. For men with a low dietary intake of beta-carotene, high-dose supplements of beta-carotene were associated with a reduced risk of prostate cancer.

"Our cohort findings, although based on relatively short follow-up, do not provide strong support for population-wide implementation of high-dose antioxidant supplementation for the prevention of prostate cancer," the authors write. "They do suggest, however, that in certain population subgroups there was an association between supplement intake and reduced risks of prostate cancer."

In an accompanying editorial, I-Min Lee, Sc.D., of Brigham and Women’s Hospital in Boston, Mass., and colleagues discuss the implications of Hayes and colleagues’ study in the context of earlier studies of vitamin E supplementation and cancer risk. The editorialists agree that the study results do not provide strong support for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data remain unclear about the benefits of vitamin E supplementation for prostate cancer prevention in the general population; however, there are strong data supporting smoking cessation to reduce cancer incidence. The authors write, "Now and in the future, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an important course of action for overall cancer prevention is to continue efforts to prevent the initiation of smoking and to promote the cessation of smoking among those who do smoke."

Ariel Whitworth | EurekAlert!
Further information:
http://www.oxfordjournals.org

More articles from Health and Medicine:

nachricht Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>