Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs

01.02.2006


A "starry sky" map linking the myriad interactions between the influenza virus and its human host will help guide researchers in creating new anti-viral drugs, say researchers at UT Southwestern Medical Center.



The on-line map, part of a project called Reactome, is intended to teach scientists about parts of the influenza lifecycle they might not be familiar with, and to help researchers look at specific reactions and figure out ways to block them.

"Understanding how influenza reacts with its host is really critical for the rational design of anti-viral drugs and new vaccines," said Dr. Richard Scheuermann, professor of pathology at UT Southwestern.


Reactome, online at www.reactome.com, was created in 2004 and includes a variety of biochemical pathways for processes such as cell death in several species, primarily human.

Individual reactions are shown as separate items, which are linked by arrows to associated reactions. The diagrams resemble constellations; hence the "starry sky" nickname.

The influenza pathway component and a simultaneous HIV database going online mark the first time Reactome has displayed interactions between an infectious pathogen and its host, Dr. Scheuermann said.

Pathogens such as influenza have evolved to use hosts to promote their growth, while at the same time blocking the host reactions that recognize and respond to infection. Each year, for example, winter is marked by the outbreak of flu caused by new viruses that the human immune system doesn’t recognize.

The new Reactome influenza database outlines a typical virus life cycle, which will be updated as more research becomes available.

"In the future, the goal is to build out all of the host-pathogen reactions," Dr. Scheuermann said.

UT Southwestern’s participation was part of the BioHealthBase Bioinformatics Resource Center project, a collaboration between Dr. Scheuermann’s lab and a bioinformatics software engineering team at Northrop Grumman Information Technology funded by the National Institute of Allergy and Infectious Diseases.

Reactome is an NIH-funded collaboration between Dr. Lincoln Stein’s laboratory at Cold Spring Harbor Laboratory in New York and the laboratory of Dr. Ewan Birney of the European Bioinformatics Institute, part of the European Molecular Biology Laboratory, in Hinxton, UK.

Aline McKenzie | EurekAlert!
Further information:
http://www.reactome.com
http://www.utsouthwestern.edu

More articles from Health and Medicine:

nachricht UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego

nachricht New cancer immunotherapy approach turns immune cells into tiny anti-tumor drug factories
05.12.2018 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

Im Focus: The force of the vacuum

Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.

The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

Inaugural "Virtual World Tour" scheduled for december

28.11.2018 | Event News

 
Latest News

A new molecular player involved in T cell activation

07.12.2018 | Life Sciences

High-temperature electronics? That's hot

07.12.2018 | Materials Sciences

Supercomputers without waste heat

07.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>