Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

PCBs, furans may factor in risk of non-Hodgkin lymphoma

02.12.2005


Scientists have found some additional evidence that environmental exposure to polychlorinated biphenyls (PCBs) may be associated with non-Hodgkin lymphoma, according to a study published in the December 1 issue of Cancer Research.



By comparing blood levels of PCBs in 100 pairs of healthy volunteers and non-Hodgkin lymphoma patients, Anneclaire De Roos, Ph.D., assistant professor of epidemiology, Fred Hutchinson Cancer Research Center, and colleagues determined that high levels of three specific molecular forms of PCBs are linked to an increased risk of developing cancer that starts in patients’ lymph tissue.

The research also disclosed a potential increased risk of non-Hodgkin lymphoma associated with high blood levels of total dibenzofurans. Furans form as a by-product of waste incineration and other industrial processes and are also present in the environment at lower levels than PCBs.


"This study strengthens the hypothesis that persistent organochlorines may be associated with risk of lymphoma" said Nathanial Rothman, a researcher in the National Cancer Institute’s Division of Cancer Epidemiology and Genetics.

"The furans are a new hypothesis, and the PCB findings provide us with some additional evidence, but these studies really need to be replicated broadly with much larger numbers of cases. Also, it is important to follow-up these findings in prospective cohort studies that collect blood samples from people when they are healthy, so that we can measure organochlorine levels before their disease develops."

Incidence of non-Hodgkin lymphoma has risen through-out the last half of the twentieth century, concurrent with the use and environmental dispersion of synthetic PCBs. Although their production has been banned for more than 25 years in the United States due to toxicological concerns, PCBs persist in the environment and remain in humans because they break down slowly.

"Though they aren’t being produced any more we still detect them in the environment, but at lower levels than in the past," Rothman said.

Nonetheless, the presence of PCBs in the environment and even in the blood of humans doesn’t mean that these compounds are cancer-causing substances, he cautioned. "There is still a good deal of uncertainty as to whether PCBs are actually causally associated with any cancer in humans." he said.

While their current report adds more evidence about PCBs and cancer, it was not designed to produce the ’smoking gun’ evidence that defines the molecular events induced by cellular exposure to PCBs resulting in initiation of cancer. Also, studies of workers with high occupational exposure to PCBs have not detected an excess of lymphoma, adding uncertainty to the relationship.

"We believe our findings could provide an important clue to the cause of NHL," Rothman said. "However, these associations need to be examined in other studies. If the relationship is consistently replicated, we need to carefully address whether or not PCBs or furans are likely to cause lymphoma, or if another risk factor that is associated with these chemicals could be the true causative agent."

Nearly 54,000 Americans will be diagnosed with non-Hodgkin lymphoma this year, according to the American Cancer Society. More than 19,000 will die from the disease. More men (23 of every 100,000) develop the lymphatic system cancer than women (16 per 100,000). Most non-Hodgkin lymphoma patients are mature adults. The average age at diagnosis is 60 years, with the average survival of patients with low-grade lymphomas about six to eight years after diagnosis. Some 30 percent of patients diagnosed with high-grade lymphomas are permanently cured after treatment, which varies by type of lymphoma and response to chemotherapies.

The De Roos study was the result of collaborations between National Cancer Institute epidemiologists led by Patricia Hartge, Sc.D., the Principal Investigator of the study; along with NCI scientists Jay Lubin, Ph.D., Joanne Colt, M.S. and Rothman at the National Institutes of Health, Department of Health and Human Services. Chemical analysis of the blood components was performed under the guidance of Larry Needham, Jr., Ph.D., with Don Patterson, Ph.D. at the Division of Laboratory Sciences, National Center for Environmental Health, Center for Disease Control and Prevention, Atlanta, Ga.. Also contributing to the study were James Cerhan, M.D., Ph.D., Mayo Clinic College of Medicine, Rochester, Minn.; Rick Severson, Ph.D., Karmanos Cancer Institute, Wayne State University, Detroit, Mich.; and Wendy Cozen, D.O., Keck School of Medicine, University of Southern California, Los Angeles, Calif.

Russell Vanderboom, Ph.D. | EurekAlert!
Further information:
http://www.aacr.org

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Quantum bugs, meet your new swatter

20.08.2018 | Information Technology

A novel synthetic antibody enables conditional “protein knockdown” in vertebrates

20.08.2018 | Life Sciences

Metamolds: Molding a mold

20.08.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>