The role of mitochondrial dysfunction in the pathogenesis of insulin resistance is a widely debated topic. It has been shown that young, lean, insulin-resistant offspring of parents with type 2 diabetes have reduced mitochondrial function. But the precise role of this decreased function in relation to insulin resistance and type 2 diabetes was not clear.
In a paper appearing online on November 10 in advance of print publication of the December issue of the Journal of Clinical Investigation, Gerald Shulman and colleagues from Yale University take muscle biopsies from these offspring and show that they have reduced mitochondrial content as assessed by electron microscopy. The subjects also have lower insulin-stimulated muscle glucose uptake and increased lipid content in muscle cells. However in contrast to two recent studies, the authors did not find any alterations in PGC-1a or PGC-1b or other downstream regulators of mitochondrial gene expression.
These results provide new insights into the earliest defects that may be responsible for the pathogenesis of type 2 diabetes. Moreover, reduced mitochondrial content could result in reduced mitochondrial function, which predisposes the offspring of type, 2 diabetic parents to muscle cell lipid accumulation, which then leads to defective insulin signaling and action.
Stacie Bloom | EurekAlert!
Purdue cancer identity technology makes it easier to find a tumor's 'address'
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Microgel powder fights infection and helps wounds heal
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Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
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