Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hopkins study finds no ’cognitive decline’ after use of heart-lung machine during bypass surgery

11.11.2005


Controlled study should reassure patients



The use of a cardiopulmonary heart pump during coronary artery bypass grafting (CABG) surgery does not significantly damage such high-level mental tasks as thinking, reasoning and remembering, according to a study by Johns Hopkins researchers recently published in Neurology.

CABG surgery is effective for the relief of angina and reducing the risk of a heart attack but has been widely feared to cause "pump-related" damage to the cerebral cortex, according to Guy M. McKhann, M.D., a professor in the Department of Neurology at The Johns Hopkins University School of Medicine.


To gauge whether there was a clinical basis for this concern, McKhann led a non-randomized study comparing the cognitive abilities of on-pump CABG patients, off-pump CABG patients, nonsurgical patients with coronary artery disease and heart- healthy individuals. The results of the study showed that on-pump CABG patients had no significant differences in their higher-level mental functions than the other groups tested, according to McKhann.

"This outcome should be reassuring to both patients and surgeons engaged in on-pump CABG surgeries," McKhann said.

The study, conducted between September 1997 and September 2003, involved 380 individuals -- 140 on-pump CABG patients, 72 off-pump CABG patients, 99 nonsurgical patients with coronary artery disease and 69 heart-healthy patients.

Both the on-pump CABG patients and the nonsurgical patients with coronary artery disease were exclusively Hopkins-based, whereas the off-pump CABG patients came from Hopkins; Sinai Hospital, Baltimore, Md.; Washington Adventist Hospital, Takoma Park, Md.; University of Maryland Medical Center, Baltimore, Md., and Pinnacle Health System, Harrisburg, Pa.

Study participants were given a battery of standardized neuropsychological tests that were repeated three months and 12 months later.

Test scores were sorted and combined into eight areas: verbal memory, visual memory, language, attention span, visuoconstruction (the ability to copy a complex figure), motor speed (the time to perform motor activity, such as writing the alphabet), psychomotor speed (the time to complete an action that requires some planning) and executive function (the ability to plan ahead and make judgments).

The Center for Epidemiologic Studies Depression scale (CESD) and Functional Status Questionnaire (FSQ) were also administered at baseline and follow-up and all subjects were tested by the same team of study investigators who traveled to all the sites in the study to examine patients. Previous test results were not reviewed before subsequent testing so that testers were unlikely to be able to bias results based on such knowledge.

Self-reporting of well-being was included in the study in the areas of memory, mental arithmetic, personality, and reading newspapers and books. For example, subjects were asked whether they thought their personality had improved, changed for the worse, or stayed the same over time and since the previous interview. Reading, defined as whether or not a patient typically read either newspapers or books, was assessed at each visit.

At the start of the study, subjects with coronary artery disease (CABG on-pump, CABG off-pump, and nonsurgical) had overall lower performance than the heart-healthy group in several cognitive domains. But by three months, all groups had improved, which McKhann says was most likely due to familiarization with the testing procedures. Between three and 12 months, there were minimal changes in individual subjects for all groups, and no consistent differences between the CABG and off-pump patients were observed.

"These results offer no evidence that the cognitive test performance of on-pump CABG patients differed from that of off-pump control groups with coronary artery disease over a one-year period," McKhann said.

Eric Vohr | EurekAlert!
Further information:
http://www.jhmi.edu

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>