Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Remarkable enhancement of productivity for drugs through new real-time quality control

06.09.2005


The Technical Research Centre of Finland, VTT has developed a new method, which increases product development cycle. This process will also enhance the competitiveness of drug development and reduce costs. VTT is working in collaboration with GlaxoSmithKline, GSK, one of the leading international pharmaceutical companies, to enhance quality control for drugs by using Process Analytical Technologies (PAT). The goal of the PAT is to develop drug process’ production analysis into real-time quality control and to decrease significantly production costs.



VTT’s optical measurement methods, in drug production, will help pharmaceutical companies increase the quality and safety of their products. Manufacturing cost of drugs play an important role in the cost of pharmaceutical products, as 40% of the price is coming from production.

One of the major problems in developing drug manufacturing processes is the lack of fast and reliable measurement techniques. At the moment, the quality measurement technique consists mainly of slow laboratory analyses, which do not enable real-time quality control. The effective manufacturing of a drug takes only one to two days whereas in practice the whole manufacturing process may take as long as 30-60 days.


VTT has one of the world’s largest groups of specialists, totally 45 man-years annual volume, developing on new process measurement equipment. At the moment, VTT has developed state-of-art optical instrumentation mainly for other process industries such as pulp&paper and metal. In this project the challenge is to transfer and utilize this Finnish process measurement knowledge to the pharmaceutical processes. VTT will collaborate with GSK to improve GSK drug manufacturing processes by using the high-tech PAT technologies.

VTT and GSK assignment is significant for VTT as the two -year project is worth up to 1.5 million Euro. The main target of this project is to create and develop new innovative measurement systems and business opportunities to Finnish measurement and sensor companies. Measurement systems will be tested in several production lines including GSK plants in UK, Italy, Spain and Canada.

Finnish industry has been to the forefront in developing strong industrial process understanding, strongly supported by the collaborative R&D work undertaken by renowned institutes such as VTT. The various R&D programs have been coordinated, advised and supported by Tekes, the Finnish national technology agency, whose strategy is to develop new international links for Finnish technology abroad.

Irene Hernberg | alfa
Further information:
http://www.vtt.fi

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>