Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Ovarian cancer risk and consumption of milk products and lactose

08.08.2005


Meta-analysis of epidemiological studies finds some support for a link



An analysis of 21 studies that have investigated the link between ovarian cancer and the consumption of milk products and lactose has found some support for the hypothesis that high intake is associated with increased cancer risk. The results of this analysis, published online August 5, 2005 in the International Journal of Cancer, the official journal of the International Union Against Cancer (UICC), found that support was stronger in cohort studies, compared to case-control studies, which offered varying results.

Since a positive correlation between ovarian cancer risk and the consumption of milk products and lactose was first reported in 1989, many epidemiological studies have further examined the relationship. However, these studies have yielded conflicting conclusions. To better understand the uncertain relationship, researchers led by Susanna C. Larsson of the National Institute of Environmental Medicine at the Karolinska Institute in Sweden, conducted a meta-analysis of relevant case-control and cohort studies.


The researchers sought reports that offered data from a case-control, or cohort study on the association between intakes of milk, yogurt, cheese or lactose, and incidence of or mortality from epithelial ovarian cancer. Studies also had to present results as an odds ratio, or relative risk, with 95 percent confidence intervals. The researchers accepted three prospective cohort studies, and 18 case-control studies and performed a meta-analysis to determine associations between consumption and cancer risk.

Their analysis found notable differences between case-control and cohort studies. Case-control studies showed low-fat milk consumption negatively associated, and whole milk consumption positively associated, with the risk of ovarian cancer, but offered no support for the involvement of lactose in the development of ovarian cancer. By contrast, prospective cohort studies indicated that high intakes of milk may increase the risk of ovarian cancer. They also revealed a 13 percent increase in ovarian cancer risk with a daily increase of 10 grams of lactose, the approximate amount in one glass of milk. When case-control and cohort studies were considered in combination, yogurt consumption was associated with a non-significant increase in cancer risk, while cheese was not associated with risk.

The differences between the findings of case-control studies and those of cohort studies could be explained by a number of factors: selection bias, recall bias or changes in dietary practices after cancer diagnosis. They might also be due to the time interval between diet assessment and illness, since cohort studies may record dietary practices decades before illness occurs, while case-control studies assess diet around the time of diagnosis. Other limitations of this study include the observational nature of the assessed studies, imprecise measurements of diet, and publication bias.

Of note, the two studies that examined histological subtypes of ovarian cancer found that the associations with milk and lactose intakes were confined to serous ovarian cancer, leading researchers to advise, "future studies should consider specific subtypes of ovarian cancer, and the interrelationship between intakes of dairy foods and lactose, genetic polymorphisms, and ovarian cancer risk."

"In conclusion," they write, "prospective cohort studies, but not case-control studies, support the hypothesis that high intakes of dairy foods and lactose may increase the risk of ovarian cancer."

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/ijc.
http://www.wiley.com

More articles from Health and Medicine:

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

nachricht Pain: Perception and motor impulses arise in the brain independently of one another
12.12.2018 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Magic number colloidal clusters

13.12.2018 | Life Sciences

UNLV study unlocks clues to how planets form

13.12.2018 | Physics and Astronomy

Live from the ocean research vessel Atlantis

13.12.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>