Core-needle biopsy guided by CT scans or ultrasound appears to be an effective way to obtain tumor samples diagnosis of pediatric solid tumors, say St. Jude Children’s Research Hospital researchers
Inserting biopsy needles through the skin appears to be a safe and reliable alternative to surgery for obtaining diagnostic samples of a suspected solid tumor in children, according to results of a study by investigators at St. Jude Childrens Research Hospital. The technique, called percutaneous ("through the skin") core-needle biopsy, provides samples of tissue suitable for accurate initial diagnosis of a solid tumor, the researchers say.
In addition, the findings contradict the belief of many pediatric surgeons that this technique is more likely than surgery to dislodge cells from the tumor and cause the cancer to spread. A report on the findings of this study appears in the August 1 issue of Cancer. The St. Jude findings are based on a retrospective ("look back") study of the medical records.
Kelly Perry | EurekAlert!
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
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